Chlorpromazine

Question 1

What is Chlorpromazine

Answer 1

A phenothiazine based antipsychotic

Question 2

On which dopaminergic-receptors is Chlorpromazine an antagonist

Answer 2

dopaminergic-receptors (subtypes D1, D2, D3 and D4), serotonergic-receptors (5-HT1 and 5-HT2), histaminergic-receptors (H1-receptors), alpha1/alpha2-receptors and muscarinic (cholinergic) M1/M2-receptors.

Question 3

what do we use now instead of Chlorpromazine

Answer 3

Prochlorperazine is preferentially used. It is from the same class of drug.

Question 4

why is Chlorpromazine used less now?

Answer 4

due to longterm side effects.

Question 5

Other actions and therapeutic uses of Chlorpromazine

Answer 5

as an antiemetic and in the treatment of intractable hiccup

Question 6

how does Chlorpromazine have antipsychotic actions?

Answer 6

long-term adaptation by the brain to blocking dopamine receptors.

Question 7

Class

Answer 7

D2 receptor antagonist

Question 8

Action

Answer 8

Antiemetic

Antipsychotic

Question 9

Mechanisms of Actions

Answer 9

Reversible competitive
antagonism of D2
receptors

Question 10

Clinical Uses

Answer 10

Nausea and vomiting
associated with cancer
chemotherapy
Radiation therapy and
general anaesthesia

Question 11

Adverse Effects

Answer 11

Extrapyramidal effects
Parkinsonian
symptoms
Hypotension
Antihistamine and
antimuscarinic actions