Misoprostol Flashcards
1
Q
Class
A
Prostaglandin E
receptor agonist
2
Q
Action
A
Promotes gastric ulcer
healing
Combats ulcerogenic
actions of NSAIDs
3
Q
Mechanism of Action
A
Activates prostaglandin receptors to inhibit acid secretion Stimulates bicarbonate and mucus secretion
4
Q
Clinical Use
A
Gastric ulcers
Abortifacient
5
Q
Adverse effects
A
Diarrhoea
Abdominal cramps
6
Q
what is Misoprosol
A
A prostaglandin mimetic
7
Q
what is misoprosol used to treat?
A
the treatment and prevention of stomach ulcers induced by NSAIDs
8
Q
how does misoprosol inhibit gastric secretion?
A
secretion by binding to the prostaglandin receptor on the parietal cell. This receptor inhibits the activity of adenylate cyclase, reducing cAMP levels, and the downstream protein kinase activity. This reduces the availability of the proton pump at the surface reducing acid secretion
