Hyoscine Flashcards
What is Hyoscine
Hyoscine: a muscarinic antagonist
What type of therapy is Hyoscine used for
Anti-emetic therapy
What is the other name for Hyoscine
Scopolamine
which receptors does Scopolamine block
blocks the muscarinic acetylcholine receptors.
what is Hyoscine used to prevent?
used to prevent motion sickness
how does Hyoscine prevent motion sickness
It is thought Ach plays an important role in communication between the vestibular system and the vomiting centre. Therefore by blocking this communication there is a reduction in the activity of the vomiting centre and a reduction in nausea
why is the mechanism of Scopolamine unclear?
However, as Scopolamine also may work directly on the vomiting centre its precise mechanism of action is unclear.
when does Scopolamine work best
Scopolamine works best before the onset of motion sickness.
Class
Muscarinic receptor
antagonist
Action
Antiemetic
Mechanisms of Actions
Reversible competitive antagonism of muscarinic receptors Antieemtic effects due to blockade of receptors in vestibular nucleus and in the vomiting centre
Clinical Uses
Motion sickness Locl gut stimuli No efficacy against chemotherapy induced emesis mediated via the CTZ
Adverse Effects
Drowsiness Amnesia Dry mouth Tachycardia Blurred vision Urinary retention
