Ondansetron

Question 1

What is Ondansetron?

Answer 1

selective serotonin 5-HT3 receptor antagonist

Question 2

describe the affinity of Ondansetron with dopamenine receptors

Answer 2

low affinity

Question 3

Where the serotonin 5-HT3 receptors are located?

Answer 3

on the nerve terminals of the vagus in the periphery, and centrally in the CTZ

Question 4

how does Ondansetron have antiemetic activity

Answer 4

is via inhibition of 5-HT3 receptors present both centrally (CTZ) and peripherally (GI tract).

Question 5

what does the is via inhibition of 5-HT3 receptors present both centrally (CTZ) and peripherally (GI tract) then do?

Answer 5

This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, and serotonin activity in the CTZ.

Question 6

what is the drug of choice for the 5-HT3 pathway now?

Answer 6

Granisetron

Question 7

Ondansetron class

Answer 7

5 HT3 antagonist

Question 8

Ondansetron action

Answer 8

Antiemetic

Question 9

Ondansetron mechanism of action

Answer 9

Reversible competitve
antagonism at 5 HT3
receptors in the CTZ and at
sensory endings of vagal
afferents in the GIT

Question 10

Ondansetron clinical use

Answer 10

Main agents for nausea
and vomiting due to
cytotoxic anticancer
drugs

Question 11

Ondansetron adverse effect

Answer 11

Headaches

GIT upsets