Ibuprofen Flashcards
1
Q
Class
A
Non-steroidal anti-
inflammatory drugs
2
Q
Actions
A
Reduces inflammation
Analgesic for
inflammaotry pain
Antipyretic
3
Q
Mechanism of Action
A
Reversible inhiition of COX
1 and weak inhibition of
COX 2
4
Q
Clinical Use
A
Inflammaotry conditions
Dysmenorrhea
5
Q
Adverse effects
A
Gastric bleeding Headache Dizziness Allergic reactions Renal toxicity
6
Q
what is ibuprofen
A
a reversible inhibitor of the COX enzyme
7
Q
what are ibuprofens pharmacological effects believed to be due to?
A
inhibition cylooxygenase-2 (COX-2)
8
Q
what happens when cylooxygenase-2 (COX-2) is inhibitted
A
decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever and swelling
9
Q
what are ibuprofens antipyretic effects believed to be due to?
A
action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
