Cyclizine

Question 1

What is Cyclizine

Answer 1

• a piperazine-derivative antihistamine

- antiemetic agent

Question 2

what is Cyclizine used for

Answer 2

used in the prevention and treatment of nausea, associated with motion sickness. used in the management of vertigo in diseases affecting the vestibular apparatus

Question 3

is the mechanism of action of Cyclizine well understood

Answer 3

no

Question 4

what effects of Cyclizine have?

Answer 4

possesses anticholinergic, antihistaminic, central nervous system depressant, and local anaesthetic effects.

Question 5

Class

Answer 5

Histamine H1 receptor antagonist

Question 6

Action

Answer 6

Antiemetic

Sedative

Question 7

Mechanisms of Actions

Answer 7

Reversible competitive
antagonist at H1 receptors
Antiemetic action is due to
blocking H1 receptors in
the vestibular nuclei and in
the vomiting centre

Question 8

Clinical Uses

Answer 8

Motion sickness and
other emesis of
vestibular origin
Vomiting in early
pregnancy
Emesis due to local
stimuli in the gut acting
via the vagus

Question 9

Adverse Effects

Answer 9

Sedative action may
not be desirable
Causes confusion in
elderly
Dry mouth
(anticholinergic
action)
Potentially fatal
respiratory depression
in infants under 2
years old