Amoxicilin Flashcards
Class
Macrolide antibiotic
for eradication of
helicobacter pylori
Action
Bactercidal
Mechanism of Action
Kills bacteria by binding to
their ribosomes to inhibit
protein synthesis
Clinical Use
Many peptic ulcers occur
secondary to H. Pylori
infection
Triple therapy
Adverse effects
GI upsets
Diarrohea
Nausea
what is amoxillin
A beta-lactam antibiotic
what types of bacteria does amoxillin fight against
a wide range of Gram-positive, and a limited range of Gram-negative organisms
which penicillin binding protein does amoxillin bind to? And where is it found
1A (PBP-1A) located inside the bacterial cell well
what does the activatation of PBP-1A prevent?
the cross-linking of two linear peptidoglycan strands, inhibiting bacterial cell wall synthesis
what is cell lysis then mediated by?
bacterial cell wall autolytic enzymes such as autolysins
what is amoxillin suceptible to?
to degradation by β-lactamase-producing bacteria
because of amoxillins suceptibility to degradation, what is it often prescribed with?
clavulanic acid to increase its susceptibility
what is clavulanic acid
a β-lactamase inhibitor
what extra effects are seen when Amoxicillin is combinded with clavulanic acid
to overcome bacterial antibiotic resistance mediated through β-lactamase production.
