Omeprazole Flashcards
1
Q
Class
A
Proton pump inhibitor
2
Q
Actions
A
Inhibition of gastric
acid secretion
3
Q
Mechanism of Action
A
Binds irreversibly to H+/K+ ATPase in the gastric parietal cells to inhibit H+ transport Is a prodrug Acdiic conditions convert the drug to the active form
4
Q
Clinical Use
A
Duodenal and peptic ulcer Gasto-oesophegal refux disease Treatment of NSAID associated ulcers More effective than H2 antagonists
5
Q
Adverse effects
A
Generally bery safe Occasionally headache, abdominal pain, diarrohea, flatulence and nausea. Long-term use can cause hypergastrininaemia
6
Q
how long does the anti-secretory effect of omeprazole occurs within?
A
within one hour of oral dosing
7
Q
what is the maximal effect of omeprazole within?
A
within two hours
8
Q
why is the effect is long lasting with an approximate 50% inhibition of acid secretion and duration of inhibition lasting upto 72 hours
A
due to prolonged irreversible binding to the parietal H+/K+ ATPase enzyme.
9
Q
what happens when omeprazole has been discontinued?
A
secretory activity will return to baseline over 3-5 days
10
Q
have Systemic effects of omeprazole in the CNS, cardiovascular and respiratory systems
A
no, not to date.
