psych 521 - 524

Question 1

describe the evolution of EPS side effects

Answer 1

1. 4hr: dystonia (muslce spasm, stiffness, oculogyric crisis)
2. 4 day: akathisia (restlessness)
3. 4 wk: bradykinesia (parkinsonism)
4. 4 mo: tardive dyskinesia

Question 2

name the 3 high potency antipyschotic drugs

Answer 2

Try to Fly High

Trifluoperazine
Fluphenazine
Haloperidol

Question 3

what is alpha 2 antagonist that release norepinephrine and 5HT?

Answer 3

Mirtazapine

Question 4

mirtazapine is also what types of potent receptor blockers?

Answer 4

5 HT2 and 5 HT3

Question 5

3 clinical app for mirtazapine

Answer 5

depressed pts with insomnia with low appetite

Question 6

what are the 2 targets for trazadone?

Answer 6

blocks 5HT2 and alpha 1 receptor

Question 7

trazadone is mainly used for what?

Answer 7

insomnia

Question 8

what is a 5HT2 receptor antagonist that is used for serotonin syndrome?

Answer 8

cyproheptadine

Question 9

3 toxicities of SSRI

Answer 9

1. GI distress
2. SIADH
3. sexual dysfunction

Question 10

7 clinical applications for SSRI?

Answer 10

depression
generalized anxiety disorder
panic disorder
OCD
bulimia
social phobias
PTSD

Question 11

3 types of drug that can cause serotonin syndrome with SSRI

Answer 11

MAO inhibitors
SNRI
TCA

Question 12

symptoms of serotonin syndrome

Answer 12

HARMED

Hyperthermia
Autonomic instability
Rash (flushing)
Myoclonus
Encephalopathy
Diarrhea

Question 13

what is venlafaxine and what is it used for?

Answer 13

SNRI, generalized anxiety, panic disorder, PTSD

Question 14

what is duloxetine and its unique clinical application?

Answer 14

SNRI, diabetic peripheral neuropathy

Question 15

name 4 SSRIs

Answer 15

Fluoxetine, paroxetine, sertraline, citalopram

Question 16

name 7 tricyclic antidepressants

Answer 16

amitriptyline
nortriptyline
imipramine
desipramine
clomipramine
doxepin
amoxapine

Question 17

5 clinical applications for tricyclic antidepressants?

Answer 17

major depression
OCD (clomipramine)
peripheral neuropathy
chronic pain
migraine prophylaxis

Question 18

name 6 atypical antipsychotics

Answer 18

olanzapine
clozapine
quetiapine
risperidone
aripiprazole
ziprasidone

Question 19

clinical uses for atypical antipsychotics?

Answer 19

MOST BAD condition

Mania
OCD
Shcizophrenia (both + and -)
Tourette

Bipolar
Anxiety disorder
Derpession

Question 20

what 2 atypical antipsychotics can cause weight gain?

Answer 20

olanzapine, clozapine

Question 21

which atypical antipsychotic can cause inc prolactin and gynecomastia?

Answer 21

risperidone

Question 22

symptoms of NMS caused by typical antipsychotics

Answer 22

FEVER

Fever
Encephalopathy
Vitals unstable
Enzymes inc
Rigidity of muscles

Question 23

treatment for NMS?

Answer 23

dantrolene (Ca2+ blocker)
D2 agonist (bromocriptine)

Question 24

what is targeted by buspirone?

Answer 24

stimulates 5-HT1a receptors

Question 25

unlike babiturates and benzo, buspirone does not interact with what?

Answer 25

alcohol

Question 26

MOA of lithium?

Answer 26

blocks phosphoinositol cascade –> dec cAMP

Question 27

side effects of lithium?

Answer 27

tremor
hypothyroidism
polyuria (nephrogenic DI)
Ebstein anomaly in newborn

Question 28

what is unique about lithium excretion by the kidney? and what other drug toxicity is it associated with?

Answer 28

lithium is mostly reabsorbed at PCT with Na+

Thiazide use is implicated in lithium toxicity in bipolar pats