Drugs

Question 1

NNRTIs stand for

Answer 1

Non-Nucleoside Reverse Transcriptase Inhibitor

Question 2

3 drugs that are NNRTI?

Answer 2

Delavirdine, Efavirenz, Nevirapine (Never Ever Deliver Phosphate!)

Question 3

HIV integrase blocker?

Answer 3

Raltegravir

Question 4

What HIV drug boosts other drug conc by inhibiting P-450?

Answer 4

Ritonavir

Question 5

what drug is contraindicated with protease inhibitor b/c it decreases PI conc?

Answer 5

Rifampin

Question 6

HIV drug that causes pancreatitis?

Answer 6

Didanosine

Question 7

what HIV drug has side effects of vivid dreams and CNS symptoms?

Answer 7

efavirenz

Question 8

3 hep C drugs?

Answer 8

ribavirin, simeprevir, sofosbuvir

Question 9

HIV drug that binds to CCR5 and inhibit gp120?

Answer 9

Maraviroc

Question 10

HIV drug that binds to gp41?

Answer 10

Enfuvirtide

Question 11

what HIV drugs don’t require phosphorylation?

Answer 11

NNRTIs (Delavirdine, Efavirenz, Nevirapine)

Question 12

what NRTI (Nucleoside) is Nucleotide?

Answer 12

Tenofovir

Question 13

what is the target of natalizumab?

Answer 13

alpha 4 integrin (WBC adhesion)

Question 14

clinical application of natalizumab?

Answer 14

MS, Crohn dz

Question 15

side effects of natalizumab?

Answer 15

risk of PML in pts with JC virus

Question 16

mech of action of ribavirin?

Answer 16

blocks guanine nucleotide synthesis by competitively inhibiting inosine monophosphate dehydrogenase

Question 17

clinical usages of ribavirin?

Answer 17

HCV, RSV

Question 18

In RSV what drug is preferred over ribavirin?

Answer 18

Palivizumab in children

Question 19

which drug blocks the HCV protease inhibitor?

Answer 19

simeprevir

Question 20

which drug blocks HCV RNA-dependent RNA pol?

Answer 20

sofosbuvir

Question 21

what drug is used for acyclovir-resistant HSV that is does not require activation by viral kinase?

Answer 21

forscarnet

Question 22

DOC for P. falciparum resistant to chloroquine?

Answer 22

artemether/lumefantrine or atovaquone/proguanil

Question 23

DOC for life treatening malaria?

Answer 23

use quinidine or artesunate

Question 24

what is the mech of chloroquine?

Answer 24

blocks detoxification of heme into hemozoin –> heme accumulates and is toxic to plasmodia

Question 25

mech of resistance of chloroquine?

Answer 25

due to membrane pump that dec intracellular conc of drug

Question 26

side effects of chloroquine?

Answer 26

retinopathy, pruritius especially in dark skinned ppl

Question 27

what are anti-mite/louse drug used to treat scabies and lice?

Answer 27

Permethrin, Malathion, Lindane

Question 28

mech of Permethrin?

Answer 28

blocks Na+ channel

Question 29

mech of Malathion?

Answer 29

acetylcholinesterase inhibitor

Question 30

mech of Lindane

Answer 30

blocks GABA channels

Question 31

what drug blocks 14 alpha demethylase and inc lanosterol conc?

Answer 31

Azoles

Question 32

which drug blocks the synthesis of sterol?

Answer 32

Azoles

Question 33

drug that blocks squalene epoxidase?

Answer 33

terbinafine

Question 34

2nd gen H1 blockers?

Answer 34

ends with “adine”

loratadine, fexofenadine, desloratadine, cetirizine

Question 35

1st gen H1 blockers?

Answer 35

diphenhydramine, dimenhydrinate, chlorpheniramine

Question 36

aspirin toxicity leads to mixed resp alkalosis and metabolic acidosis, what would be the values of gas panel?

Answer 36

low pCO2 (resp alkalosis) and low bicarb (metabolic acidosis)

Question 37

two methylxanthines (theophylline) toxicities?

Answer 37

cardiotoxicity, neurotoxicity

Question 38

alpha 2 agonist used for glaucoma?

Answer 38

brimonidine