Drugs Flashcards

1
Q

NNRTIs stand for

A

Non-Nucleoside Reverse Transcriptase Inhibitor

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2
Q

3 drugs that are NNRTI?

A

Delavirdine, Efavirenz, Nevirapine (Never Ever Deliver Phosphate!)

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3
Q

HIV integrase blocker?

A

Raltegravir

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4
Q

What HIV drug boosts other drug conc by inhibiting P-450?

A

Ritonavir

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5
Q

what drug is contraindicated with protease inhibitor b/c it decreases PI conc?

A

Rifampin

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6
Q

HIV drug that causes pancreatitis?

A

Didanosine

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7
Q

what HIV drug has side effects of vivid dreams and CNS symptoms?

A

efavirenz

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8
Q

3 hep C drugs?

A

ribavirin, simeprevir, sofosbuvir

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9
Q

HIV drug that binds to CCR5 and inhibit gp120?

A

Maraviroc

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10
Q

HIV drug that binds to gp41?

A

Enfuvirtide

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11
Q

what HIV drugs don’t require phosphorylation?

A

NNRTIs (Delavirdine, Efavirenz, Nevirapine)

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12
Q

what NRTI (Nucleoside) is Nucleotide?

A

Tenofovir

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13
Q

what is the target of natalizumab?

A

alpha 4 integrin (WBC adhesion)

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14
Q

clinical application of natalizumab?

A

MS, Crohn dz

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15
Q

side effects of natalizumab?

A

risk of PML in pts with JC virus

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16
Q

mech of action of ribavirin?

A

blocks guanine nucleotide synthesis by competitively inhibiting inosine monophosphate dehydrogenase

17
Q

clinical usages of ribavirin?

A

HCV, RSV

18
Q

In RSV what drug is preferred over ribavirin?

A

Palivizumab in children

19
Q

which drug blocks the HCV protease inhibitor?

A

simeprevir

20
Q

which drug blocks HCV RNA-dependent RNA pol?

A

sofosbuvir

21
Q

what drug is used for acyclovir-resistant HSV that is does not require activation by viral kinase?

A

forscarnet

22
Q

DOC for P. falciparum resistant to chloroquine?

A

artemether/lumefantrine or atovaquone/proguanil

23
Q

DOC for life treatening malaria?

A

use quinidine or artesunate

24
Q

what is the mech of chloroquine?

A

blocks detoxification of heme into hemozoin –> heme accumulates and is toxic to plasmodia

25
Q

mech of resistance of chloroquine?

A

due to membrane pump that dec intracellular conc of drug

26
Q

side effects of chloroquine?

A

retinopathy, pruritius especially in dark skinned ppl

27
Q

what are anti-mite/louse drug used to treat scabies and lice?

A

Permethrin, Malathion, Lindane

28
Q

mech of Permethrin?

A

blocks Na+ channel

29
Q

mech of Malathion?

A

acetylcholinesterase inhibitor

30
Q

mech of Lindane

A

blocks GABA channels

31
Q

what drug blocks 14 alpha demethylase and inc lanosterol conc?

A

Azoles

32
Q

which drug blocks the synthesis of sterol?

A

Azoles

33
Q

drug that blocks squalene epoxidase?

A

terbinafine

34
Q

2nd gen H1 blockers?

A

ends with “adine”

loratadine, fexofenadine, desloratadine, cetirizine

35
Q

1st gen H1 blockers?

A

diphenhydramine, dimenhydrinate, chlorpheniramine

36
Q

aspirin toxicity leads to mixed resp alkalosis and metabolic acidosis, what would be the values of gas panel?

A

low pCO2 (resp alkalosis) and low bicarb (metabolic acidosis)

37
Q

two methylxanthines (theophylline) toxicities?

A

cardiotoxicity, neurotoxicity

38
Q

alpha 2 agonist used for glaucoma?

A

brimonidine