path page 229 - 233 Flashcards
what tissue mediator is associated with induction of vascular remodeling and smooth muscle cell migration?
PDGF
what tissue mediator stimulates fibroblast growth for collagen synthesis?
PDGF
what stimulates angiogenesis? (Name 2.)
FGF, VEFG
enzyme responsible for tissue remodeling?
metalloproteinases
name 3 roles of TGF-B
- angiogenesis
- fibrosis
- cell cycle arrest
what stimulates cell growth via tyrosine kinase?
EGF
EGF binds to EGFR which is expressed by what gene?
ERBB2
name 2 mediators that stimulate angiogenesis?
FGF, TGF-B
name 3 phases of wound healing process?
- inflammatory (up to 3 days after wound)
- proliferative (day3 - weeks)
- remodeling (1week - 6 months after wound)
what wound healing process is associated with deposition of granulation tissue and collagen, agniogeneiss and epithelial cell proliferation?
proliferative (3days - weeks)
during what period does type 3 collagen is replaced by type 1?
remodeling (1 week - 6+ months)
what is the advantage of having type 1 collagen instead of type 3?
higher tensile strength of tissue
metalloproteinase works during what phase of wound healing process?
remodeling (1 week - 6 month)
what wound phase healing is associated with dissolution of clot and wound contraction?
proliferative (day3 - 1 week)
which cell mediates wound contraction?
myofibroblast
at what point does macrophage clear debris?
2 days after the wound
what are the 3 main mediators during the inflammatory phase of wound healing?
platelets, neutrophils, macrophages
why is it important to test for latent TB before you give anti-TNF therapy?
anti-TNF drugs can cause sequestering granulomas to break down, leading to disseminated dz