p 458 basal ganglia Flashcards

1
Q

in basal gangila what are the 2 pathways that stimulate movement?

A
  1. direct pathway

2. indirect pathway

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2
Q

explain the role of dopamine in terms of its ability to stimulate movement

A

dopamine always make you move by inhibiting indirect pathway and stimulating direct pathway

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3
Q

what dopamine receptor does direct pathway use?

A

D1

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4
Q

D2 is used by what pathway?

A

indirect

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5
Q

basal ganagia is important in (what particular moveiment?)

A

voluntary movements and making postural adjustment

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6
Q

basal ganglia receives cortical input and provides

A

negative feedback to cortex to modulate movement

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7
Q

striatum is made of what 2 components?

A
  1. putamen (motor)

2. caudate (cognitive)

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8
Q

lentiform is made of what 2 components?

A
  1. putamen

2. globus pallidus

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9
Q

explain the excitatroy pathway

A

cortical inputs stimulate the striatum –> releases GABA which blocks the thalamus via the GPi/SNr –> leads to inc motion

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10
Q

explain the inhibitory pathway

A

cortical inputs stimulate the striatum –> blocks STN (subthalamic nucleus) via GPe (globus pallidus internus) and STN stimulates GPi/SNr to inhibit the thalamus –> dec motion

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