GI Flashcards
normal allele for alpha1 antitrypsin
PiM/PiM
mutant allele for alpha1 antitrypsin
PiZ/PiZ
infections associated with Reye syndrome
VZV, influenza that has been aspirin
symptoms of Reye syndrome?
mitochondrial abnormalities, fatty liver (microvesicular fatty change)
in Budd Chiari, thrombosis/compression of hepatic veins takes place with
centrilobular congestion (zone 3)
zone 3 of the liver is
pericentral vein zone = centrilobular zone
zone 3 of the liver 4 characteristics?
- affected 1st by ischemia
- contains P450 system
- most sensitive to metabolic toxins
- site of alcoholic hepatitis
4 conditions that are associated with Budd-Chiari?
- hypercoagulable state (pregnancy)
- polycythemia vera
- postpartum state
- HCC
appearance of the liver in Budd-Chiari?
mottled appearance (nutmeg liver)
what liver tumor is associated with progesterone (oral contraceptive) or anabolic steroid use?
hepatic adenoma
symptoms of hepatic adenoma?
abdominal pain/shock, may spontaneously regress or rupture
liver tumor of endothelial origin?
angiosarcoma
what can cause angiosarcoma?
arsenic, vinyl chloride, thorotrast (contrast agent)
what is the common liver tumor that is contraindicated b/c of risk of hemorrhage?
cavernous hemangioma
cirrhosis with PAS +?
alpha 1 antitrypsin def