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Step 1 Crush 250! - Hans > Immunology p213 - 217 > Flashcards

Immunology p213 - 217 Flashcards

1
Q

name 3 autoantibodies for polymyositis, dermatomyositis?

A

Anti-Jo-1, anti-SRP, anti-Mi-2

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2
Q

name 2 autoantibodies for Hashimoto thyroiditis?

A

Antimicrosomal, antihyroglobulin

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3
Q

autoantibody for autoimmune hepatitis?

A

anti-smooth muscle

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4
Q

what path is associated with anti-Ro, anti-La?

A

Sjogren syndrome

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5
Q

autoantibody for Mixed connective tissue dz?

A

Anti-U1 RNP (ribonucleoprotein)

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6
Q

autoantibody for limited scleroderma (CREST)?

A

anticentromere

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7
Q

autoantibody for scleroderma (diffused)?

A

anti Scl 70

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8
Q

what is another name for anti Scl 70?

A

anti-DNA topoisomerase 1

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9
Q

what path is associated with anti-glutamic acid decarboxylase (GAD 65)?

A

type 1 DM

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10
Q

what immune def dz is associated with chronic diarrhea, thrush, recurrent viral, bacterial, fungal, and protozoal infection?

A

SCID

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11
Q

what is the most common defect in SCID?

A

defective IL-2R gamma chain

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12
Q

what is the CD number for alpha chain of IL-2 receptor?

A

CD25

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13
Q

what T cell has CD25?

A

Reg T cell

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14
Q

CD25 polymorphism is associated with what paths?

A

autoimmune dz (MS, DM type 1)

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15
Q

what path is associated with dec T cell receptor excision circle?

A

SCID

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16
Q

name all the immune def paths that are associated with absent thymic shadow on CXR

A

Thymic aplasia (DiGeorge) and SCID

17
Q

recurrent viral/fungal infection is mainly due to what type of cell def?

A

T cell

18
Q

recurrent bacteria/protozoa infection is mainly due to what type of cell def?

A

B cell

19
Q

name 2 tests that can be used to diagnose chronic granulomatous dz?

A
  1. abnormal dihydrorhodamine (flow cytometry) test

2. neg. nitroblue tetrazolium dye reduction test

20
Q

what is the normal result for nitroblue tetrazolium dye reduction test?

A

blue, so in CGD the test result is colorless

21
Q

what path is associated with giant granules in granulocytes and platelets, pancytopenia, mild coagulation defects?

A

chediak higashi syndrome

22
Q

what path is associated with inc AFP, dec in IgA, IgG, IgE?

A

ataxia telangiectasia

23
Q

what path is associated with def of Th17 cells du to STAT3 mutation?

A

autosomal dominant hyper IgE syndrome

24
Q

what is another name for autosomal dominant hyper IgE syndrome

A

Job syndrome

25
Q

what are 2 paths associated with dec IFN gamma?

A

IL-12 receptor def, Job syndrome (autosomal dominant hyper IgE syndrome)

26
Q

what path is associated with disseminated mycobacterial and fungal infections that may present after administration of BCG vaccines

A

IL-12 receptor def

27
Q

most common primary immunodef?

A

selective IgA def

28
Q

define syngeneic graft

A

graft from identical twin or clone

29
Q

what is the other term for syngeneic graft?

A

isograft

30
Q

what type of transplant rejection present with vasculitis of graft vessels with dense interstitial lymphocytic infiltrate

A

acute

31
Q

what type of transplant rejection present with proliferation of vascular smooth muscle and parenchymal fibrosis

A

chronic

32
Q

what type of transplant rejection is dominant by arteriosclerosis?

A

chronic

33
Q

give an organ specific example of chronic rejection in the lung

A

bronchiolitis obliterans

34
Q

give an organ specific example of chronic rejection in the heart

A

accelerated atherosclerosis

35
Q

give an organ specific example of chronic rejection in the kidney

A

chronic graft nephropathy

36
Q

give an organ specific example of chronic rejection in the liver

A

vanishing bile duct syndrome

37
Q

what path is associated with T cells unable to reorganize actin cytoskeleton?

A

wiskott-aldrich syndrome

Step 1 Crush 250! - Hans (41 decks)

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