Immunology p213 - 217 Flashcards
name 3 autoantibodies for polymyositis, dermatomyositis?
Anti-Jo-1, anti-SRP, anti-Mi-2
name 2 autoantibodies for Hashimoto thyroiditis?
Antimicrosomal, antihyroglobulin
autoantibody for autoimmune hepatitis?
anti-smooth muscle
what path is associated with anti-Ro, anti-La?
Sjogren syndrome
autoantibody for Mixed connective tissue dz?
Anti-U1 RNP (ribonucleoprotein)
autoantibody for limited scleroderma (CREST)?
anticentromere
autoantibody for scleroderma (diffused)?
anti Scl 70
what is another name for anti Scl 70?
anti-DNA topoisomerase 1
what path is associated with anti-glutamic acid decarboxylase (GAD 65)?
type 1 DM
what immune def dz is associated with chronic diarrhea, thrush, recurrent viral, bacterial, fungal, and protozoal infection?
SCID
what is the most common defect in SCID?
defective IL-2R gamma chain
what is the CD number for alpha chain of IL-2 receptor?
CD25
what T cell has CD25?
Reg T cell
CD25 polymorphism is associated with what paths?
autoimmune dz (MS, DM type 1)
what path is associated with dec T cell receptor excision circle?
SCID
name all the immune def paths that are associated with absent thymic shadow on CXR
Thymic aplasia (DiGeorge) and SCID
recurrent viral/fungal infection is mainly due to what type of cell def?
T cell
recurrent bacteria/protozoa infection is mainly due to what type of cell def?
B cell
name 2 tests that can be used to diagnose chronic granulomatous dz?
- abnormal dihydrorhodamine (flow cytometry) test
2. neg. nitroblue tetrazolium dye reduction test
what is the normal result for nitroblue tetrazolium dye reduction test?
blue, so in CGD the test result is colorless
what path is associated with giant granules in granulocytes and platelets, pancytopenia, mild coagulation defects?
chediak higashi syndrome
what path is associated with inc AFP, dec in IgA, IgG, IgE?
ataxia telangiectasia
what path is associated with def of Th17 cells du to STAT3 mutation?
autosomal dominant hyper IgE syndrome
what is another name for autosomal dominant hyper IgE syndrome
Job syndrome
what are 2 paths associated with dec IFN gamma?
IL-12 receptor def, Job syndrome (autosomal dominant hyper IgE syndrome)
what path is associated with disseminated mycobacterial and fungal infections that may present after administration of BCG vaccines
IL-12 receptor def
most common primary immunodef?
selective IgA def
define syngeneic graft
graft from identical twin or clone
what is the other term for syngeneic graft?
isograft
what type of transplant rejection present with vasculitis of graft vessels with dense interstitial lymphocytic infiltrate
acute
what type of transplant rejection present with proliferation of vascular smooth muscle and parenchymal fibrosis
chronic
what type of transplant rejection is dominant by arteriosclerosis?
chronic
give an organ specific example of chronic rejection in the lung
bronchiolitis obliterans
give an organ specific example of chronic rejection in the heart
accelerated atherosclerosis
give an organ specific example of chronic rejection in the kidney
chronic graft nephropathy
give an organ specific example of chronic rejection in the liver
vanishing bile duct syndrome
what path is associated with T cells unable to reorganize actin cytoskeleton?
wiskott-aldrich syndrome
