peds43 Flashcards
other features in alagille syndrome
cardiac disease, renal disease, eye anomalies, msk anomalies, growth failure, panc insuff, hypercholesterolemia
wilsons diseae
may cause acute and chornic hep and liver filure
viruses besides the hepatitis A-E that can cause hepatitis
EBV, varicell-zoster, HIV, HSV
heo A transmission
fecal-oral (contaminated food and water)
most common hep virus causing infection
hep a
why is transmission scary?
because virus is shed in the stool 2-3 weeks before onset of symptoms and 1 week AFTER the onset of jaundice
incub period for hep a
206 weeks
infection clinical features?
asymp in majority of kids; jaundice rare;
igM anti-HAV
present early and persisits for up to 6 monhts
igG anti-HAV
also present early but confers lifelong immunity
hep a is Rna
right
hep b is dna
right
transmission of hep b
perinatal, or exposure to infected blood or bodily secretions (tears, saliva, semen, feces, etc)
incub for hep b
45-160 days
symptoms of hep B
range from asymp to nonspec systemic illness to liver failure
chronic hbv infection
most common in infants who acquired through the birth canal; have incr risk of hepatocellular carcinoma
hbsAg
pathognomonic for active disease
HbsAb
from vaccination or natural infection; it is protective
HBcAb
natural infection and persisits lifelong
HBeAg
rises very early in active infection and therefore useful in dx acute infection
hep c- dna or rna?
rna
transmission of hep c
perinatal or parenteral exposure
clinical features of hep c infection?
acute is rarely symptomatic, whereas chronic may result in cirrhosis and hepatic fibrosis; chronic infection occurs in 80%
hep D- dna or rna?
rna virus
