Pathology: Small Bowel Flashcards

1
Q

what are the two possible causes of ischaemia of the small bowel?

A

mesenteric artery occlusion

non occlusive perfusion insufficiency

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2
Q

what two things can cause mesenteric artery occlusion?

A

mesenteric artery atherosclerosis

thromboembolism from the heart

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3
Q

name four things that can cause non occlusive perfusion insufficiency

A

shock
strangulation of the bowel
drugs
hyperviscosity

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4
Q

is bowel ischaemia usually acute or chronic?

A

acute

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5
Q

what is the most metabolically active part of the bowel wall, and what does this mean in terms of ischaemia?

A

the mucosa

means it is the most sensitive to the effects of hypoxia

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6
Q

when does most tissue damage occur in non-occlusive ischaemia?

A

after reperfusion

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7
Q

name the three types of intestinal infarct, from lowest to highest degree

A

mucosal
mural
transmural

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8
Q

what is meckel’s diverticulum the result of?

A

incomplete regression of the vitello intestinal duct

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9
Q

what might a meckel’s diverticulum contain?

A

heterotopic gastric mucosa

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10
Q

name three possible complications of meckel’s diverticulum

A

bleeding
perforation
diverticulitis

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11
Q

list the primary tumours that can occur in the small bowel

A

lymphoma
carcinoid tumour
carcinomas

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12
Q

which is more common, a primary or a secondary tumour in the small bowel?

A

secondary

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13
Q

what type of lymphomas are found in the small intestines?

A

non-hodgkins

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14
Q

how is lymphoma of the small bowel treated?

A

surgery and chemotherapy

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15
Q

what is the most common site for a carcinoid tumour?

A

the appendix

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16
Q

name two diseases associated with carcinoma of the intestine

A

crohn’s and coeliac

17
Q

what gene has a strong association with coeliac disease?

A

HLA B8

18
Q

what cell mediates coeliac disease?

A

intraepithelial lymphocytes

19
Q

where are lesions worst in coeliac disease?

A

proximal bowel

20
Q

what test is very sensitive for coeliac disease?

A

duodenal biopsy

21
Q

what three antibodies does serology for coeliac disease look for?

A

anti-TTG
anti-endomesial
anti-gliadin