Pathogenesis of Dementia Flashcards
What pathological process occurs in the substantia nigra in Parkinson’s?
Accumulation of lewy bodies
How much of Alzheimer’s is genetic?
90%
What are neurofibrillary tangles?
Accumulations of tau protein that are markers of the progression of AD
What cause synaptic chaos in AD?
Abeta peptide dispersing in the brain and planting in the membrane at synapses
How does neuronal tissue with BSE appear microscopically?
There are fluid filled vacuoles within the cytoplasm of cells
What is best target for a disease modifying drug in AD?
Abeta oligomer
Which part of the brain is most commonly effected in AD first?
The medial temporal lobe
Where is Kuru found predominantly?
Papua New Ginea
What is the causative agent in transmissible spongiform encephalopathies?
Aberrant protein
What is the proper name of mad cow’s disease?
Bovine spongiform encephalitis
What is the name of the peptide at the centre of AD?
Abeta
What are some risk modifying factors for ADs?
Education
Smoking
Vascular disease
Diabetes
Head trauma
Antioxidants
- their relative effect is small though
Why can’t beta sheets be cleared in Alzheimer’s?
They are insoluble
What is a more important cause of deficit in ADs, amyloid plaques or Abeta peptide?
Abeta peptide
What drives that accumulation of neurofibrillary tangles?
Abeta peptide
