CNS Transmission Flashcards
What is the difference between catecholamine production in the CNS and adrenal gland?
NA > adrenaline is possible in the adrenal glands while synthesis stops at NA in neurons
Why are there prejunctional receptors for NA?
It is a negative feedback mechanism to regulate its release
What is the affect of cocaine on neural activity
Increased responsiveness to neuronal activity
What is the mechanism of action of Amphetamines and ephedrine?
It displaces NA from the presynaptic vessels it is contained in causing it to be released non-exocytotically
What goes wrong in Parkinson’s?
Degeneration of dopaminergic pathways
Is GABA excitatory or inhibitory?
Inhibitory
What is the neurotransmitter and receptor of the sympathetic NS?
Noradrenaline
Alpha and beta adrenoceptors
How can cocaine be used as an anaesthetic?
Block Na channels
What is the neurotransmitter and receptor of the parasympathetic NS?
Acetylcholine
Muscarinic receptors
What is the mechanism of action of cocaine?
It blocks NA (and other neurotransmitters) reuptake into the presynaptic neurone
The receptors for GABA and glutamate are what type?
Ligand gated ion channels
What is the mechanism for removal of NA from the synapse?
Reuptake
What aspect of cocaine’s affect is causes people to be come dependent?
Dopaminergic action (ie blocking dopamine reuptake at the synapse)
The physiological response to cocaine is indicative of … stimulation?
Sympathetic NS
Why is L-DOPA used as a treatment for Parkinson’s and not dopamine itself?
L-DOPA can get across the BBB (via AA transporters), dopamine can’t
