Parasitology Flashcards
____ within host
Endoparasites
Unlike bacterial and viral infections, parasitic infections are often ____
Chronic (lasting months to years)
Most parasites (>90%) are ____
Protozoan (single celled)
____ cause 80-90% of parasitic infections
Protozoa
Name 6 protozoa that cause disease
- Entamoeba histolytica
- Entamoeba gingivalis
- Trichomonas tenax
- Giardia lamblia
- Balantinium coli
- Cryptosporidium parvum
Which phase of protozoa is for feeding?
Trophozoite
Which phase of protozoa is infective?
Cyst
E. histolytica infection route
Fecal-oral
E. histolytica causes what disease?
Amoebic dysentary
DOC for E. histolytica
Metronidazole
E. gingivalis route of infection
Oral-oral (kissing, sharing eating utensils)
T. tenax infects the ___
Mouth
T. vaginalis infects the ____
GU tract
What is the name of the disease that Trichomonas causes?
Trichomoniasis
What is the most common US parasitic infection?
Trichomoniasis
DOC for Trichomonas
Metronidazole
____ lacks cyst phase
T. tenax
Giardia lamblia is a ____
Diplomonad
G. lamblia DOC
Metronidazole
____ showers in stool
Giardia
Giardia causes what disease?
Giardiasis
Symptoms of GIardiasis
- Protein malabsorption
- Persistent bad breath
- Belching that smells of sulfur
Giardiasis is a problem for:
Immunocompromised
What is the only pathogenic ciliated protozoa sp.?
B. coli
B. coli causes what disease?
Balantidiasis
DOC for B. coli
Metronidazole
____ causes secondary liver infection
B. coli
Cryptosporidiosis is caused by what 2 protozoa?
- C. parvum
- C. hominis
Crysptosporidium host and reservoir can be:
Humans
Cryptosporidium spores (cysts) are resistant to:
- Chlorine disinfection
- UV
Name 2 infective Plasmodium species
- P. falciparum
- P. vivax
What does Plasmodium cause?
Malarial disease
____ causes deadly malaria
P. falciparum
____ causes recurrent malaria
P. vivax
What is the vector for Plasmodium?
Female anopheles mosquito
Plasmodium is a _____ parasite
Obligate intracellular
Plasmodium requires ____ hosts
2 (Female Anopheles mosquito, then human)
Plasmodium sporozoites infect the ____
Liver
Plasmodium merozoites infect the ____
RBC’s
Malaria can cause what kind of fevers?
- Tertian fever (every third day, after 48 hours)
- Quartan fever (every 4th day, after 72 hours)
Malaria symptoms
- Anemia
- Pallor of oral mucosa
- Jaundice
Diagnosis of malaria requires:
Blood smear
Malaria DOC
Chloroquine (inhibits DNA gyrase)
Chloroquine (CQ) and HCQ are also known as:
Zinc ionophores
Zinc non-specifically inhibits:
Viral RNA dependent RNA polymerase
Toxoplasma gondii is a ____ parasite
Intracellular
T. gondii ultimate host
Cat
True or false: T. gondii has only sexual reproduction
False - both asexual and sexual
T. gondii zygotes are released as oocysts in ____
Feces
T. gondii enter macrophages and monocytes and become ____. In the brain and muscle, they become ____
Tachyzoites; bradyzoites
T. gondii route of transmission
Consumption of contaminated meat (cats, pigs, pork chop)
Toxoplasmosis causes more severe symptoms in ____, such as ____
Immunocompromised; toxoplasma encephalitis
Toxoplasmosis in pregnancy can cause:
Early infection (less common, more serious)
Toxoplasmosis DOC
If pregnant?
pyrimethamine; spiramycin
T. cruzi is a ____
Trypanosome
T. cruzi causes what disease?
Chagas’ disease
T. brucei causes ____
African sleeping sickness
____ cause buccal necrosis
Trypanosomes
Leishmaniasis incubation period
Weeks to year
Leishmaniasis causes ____ vs. ____ disease. Name 3
- Cutaneous vs. visceral
- Persistent oral/nasal lesions
- Persistent hemorrhagic gingiva
- Periodontitis, tooth exfoliation
Leishmaniasis promastigotes are phagocytized by ____
Macrophage (rupture macrophage)
N. fowleri causes what disease?
PAM (Primary Amoebic Meningoencephalitis)
Most common sign of helminthic infection
Eosinophilia
Helminth treatments often include:
Mebendazole
____ fight against helminthic infections
Eosinophils
Helminthic infection - what do IgA and IgM do?
Coat eggs and helminths to prevent new adherence and further colonization
Helminthic infection - what does IgE do?
DIstinct response to adherent helminths
Eosinophils, basophils, mast cells found in high concentrations where in the body?
- Skin
- Respiratory tract
- GI tract
FCeRI degranulation releases:
- Major basic protein
- Eosinophil cationic protein
What is the most common helminthic infection worldwide?
Ascaris lumbricoides (largest parasitic nematode)
Ascaris lumbricoides DOC
Mebendazole
Trichinella spiralis is a nematode known as:
Roundworm
Ascaris is known as ____
Roundworm
____ is the smallest human nematode
Trichinella spiralis
Trichinella spiralis causes what disease?
Trichonosis (pork worm)
Trichinella spiralis DOC
Mebendazole
Enterobius vermicularis is a nematode known as:
Pinworm
What is the most common helminthic infection in the US?
Enterobius vermicularis
Enterobius vermicularis causes:
Daycare itch
Trichuris Trichiuria is a nematode called ____
Whipworm
What is Taenia?
Cestode known as tapeworm
You can get Trematode by eating:
Undercooked fish, crabs, crayfish
____ is the common liver fluke
Fasciola hepatica
Fasciola hepatica cause disease where?
Liver, gallbladder, bile duct