Exam 3 Hepatitis C

Question 1

Hepatitis C structure

Answer 1

• Enveloped
• Icosahedral
• positive strand ssRNA

Question 2

HCV viral glycoproteins E1 and E2 are subject to:

Answer 2

Extensive mutation

Question 3

HCV genotype ___ is most common

Answer 3

Type 1

Question 4

____ predicts HCV treatment success and response to therapy

Answer 4

Genotype

Question 5

HCV transmission routes

Answer 5

• Injection (IV) drug use
• Needlestick injuries in health care settings (1.8% transmission)
• receiving donated blood
• through HCV-infected mother during birth

Question 6

Inefficient spread of HCV involves:

Answer 6

HIV infected MSM

Question 7

Infrequent spread of HCV involves:

Answer 7

Outbreaks relating to health care, invasive, and/or injection procedures

Question 8

HCV acute infection recovery rate

Answer 8

15-25%

Question 9

HCV chronic infection rate

Answer 9

75-85%

Question 10

Chronic HCV infection leads to:

Answer 10

• Cirrhosis
• Hepatocellular carcinoma

Question 11

HCV incubation

Answer 11

2-12 weeks

Question 12

Only ____% of HCV infections will show acute symptoms

Answer 12

20-30

Question 13

HCV carrier is defined as:

Answer 13

> 6 months HCV RNA (often recognized by chance)

Question 14

Most with HCV chronic infection are _____ for decades

Answer 14

Asymptomatic

Question 15

What is the most common reason for liver transplantation in the US?

Answer 15

HCV chronic infection

Question 16

Hepatitis A, B, C are vastly _____

Answer 16

Underreported

Question 17

Standard precautions for HCV healthcare setting

Answer 17

Follow injection safety and other infection control practices consistently

Question 18

How is HCV spread in health care settings?

Answer 18

• Sharing needles and/or syringes
• Blood contaminated injectable medications/IV solutions via drug diversions

Question 19

Bad HCV practice - what happened?

Answer 19

• Staff used new needle but reused old syringe
• Stock medicine vial contaminated with HCV and infected subsequent patients

Question 20

Is there a vaccine for HCV?

Answer 20

No (Anti-HCV not protective)

Question 21

HCV diagnosis methods

Answer 21

PCR, ELISA, genotype testing

Question 22

PCR for HCV RNA can be both ____ and ____

Answer 22

Qualitative (presence or absence of virus) and quantitative (amount of RNA present)

Question 23

For HCV treatment of acute infection, there is ____ effective prophylaxis and _____ specific treatment recommended

Answer 23

No; No

Question 24

Newer treatment called ____ can be ____ effective but ______

Answer 24

Direct acting antiviral (DAA); 93-99%; very expensive

Question 25

Genotypes 1, 4, 5, 6 can be treated with which DAA?

Answer 25

Harvoni