Exam 5 Rhabdovirus (Rabies)

Question 1

Rabies lyssavirus (RABV) is part of what family?

Answer 1

Rhabdoviridae

Question 2

____ is responsible for vast majority of all human rabies cases

Answer 2

Rabies lyssavirus

Question 3

Rhabdovirus classification

Answer 3

• Enveloped
• Helical
• ssRNA (negative sense)

Question 4

Rhabdoviruses cause:

Answer 4

Brain inflammation (encephalitis)

Question 5

Primary reservoir hosts of all lyssaviruses

Answer 5

Bats

Question 6

Rabies transmission usually through carnivore hosts such as:

Answer 6

• Bats
• Raccoon
• Grey fox
• Striped skunk

Question 7

Rhabdovirus is ____ found among hares, rabbits, guinea pigs, hamsters, squirrels, mice and rats

Answer 7

Rarely

Question 8

Rabies is transmitted via

Answer 8

Broken skin (animal bites)

Question 9

True or false: human rabies is common in the US

Answer 9

False - rare

Question 10

19 cases of rabies associated with what animal?

Answer 10

Bats (>90%)

Question 11

What % of pets are vaccinated for rabies?

Answer 11

> 99.5%

Question 12

What % of rabid animals in the US are wildlife species?

Answer 12

91% (bats, raccoons, skunks, foxes)

Question 13

Globally, >99% of rabies cases are the direct result of:

Answer 13

Feral dog bites

Question 14

When rabies virus travels through nerves to spinal cord and brain, are there signs of illness?

Answer 14

No

Question 15

When the rabies virus multiplies in the brain and travels to salivary glands and organs, are there signs of illness?

Answer 15

Yes, begin to show disease signs and death occurs within 7 days

Question 16

Symptoms of rabies

Answer 16

Hydrophobia (fear of water)

Question 17

___ develop furious rabies with hydrophobia
____ develop paralytic rabies without hydrophobia

Answer 17

80%; 20%

Question 18

True or false: Rabies is nearly always fatal once clinical signs appear

Answer 18

True

Question 19

Rhabdovirus replication occurs in ___ and forms ___

Answer 19

Cytoplasm; Negri bodies

Question 20

Rabies post-exposure prophylaxis within ____ can prevent disease. ___% effective

Answer 20

10 days; 100%

Question 21

What is the rabies PEP treatment?

Answer 21

One dose of immune globulin (HRIG) and four doses of rabies vaccine