2/7 Nguyen Other DNA Viruses Flashcards
Adenovirus family
Adenoviridae
Adenovirus structure
- Naked
- Icosahedral
- dsDNA
What are the subgroups of Adenovirus?
A-F (A, B1, B2, C, D, E, F)
Each subgroup of Adenovirus has different _____
Tropisms
Adenovirus B1 tropism
Respiratory
Adenovirus B2 tropism
Renal
Adenovirus C tropism
Respiratory
Adenovirus D tropism
Ocular and other
Adenovirus E tropism
Respiratory
Adenovirus F tropism
Intestinal
Adenovirus capsule contains ____ which binds to ____ on host cell membranes to gain entry into the cell
Penton base; CAR (Coxsackiecirus and adenovirus receptor)
Adenovirus is a great _____
Vector for vaccines and gene therapy
Adenovirus was used as a vector in which well known vaccine?
Janssen (COVID) vaccine
contains DNA encoding spike protein
Adenovirus common clinical presentations
- Respiratory
- Conjunctivitis
- Gastroenteritis
Adenovirus respiratory clinical presentation
Colds
Adenovirus ____ can cause conjunctivitis
Group D (ocular mucosa, highly contagious)
Adenovirus ____ can cause gastroenteritis/diarrhea
Group F (serotypes 40-42)
Adenovirus mode of spread
Person to person; coughing or sneezing (spreads like the common cold)
Adenovirus can produce severe complications in ____, such as ____
Immunocompromised patients; viremia
can spread to skin and multiple organs
Poxviridae contains what viruses?
- Smallpox
- Cowpox
- Vaccinia
- Monkeypox
- Molluscum contagiosum
What are the two smallpox variants?
- Variola major (more severe)
- Variola minor (less severe)
Of the two smallpox variants, ____ is more severe and has a 30-50% mortality
Variola major
What strains are used to make smallpox vaccines?
- Cowpox (originally used)
- Vaccinia (currently used)
What pox viruses are related to smallpox?
- Monkeypox
- Molluscum contagiosum (MCV)
Poxviruses are the _____ of dsDNA viruses. They have _____ replication
Largest; atypical