Papillomaviridae - Bovine Flashcards
What age group is most susceptible?
Calves and yearlings but all ages are susceptible
Can horses be infected by cattle papilloma?
Yes after horses are exposed to cattle.
How is it transmitted?
Contaminated fomites
Sexual tranmission of venereal warts
What types cause Firopapilloma?
Bovine papillomavirus 1, 2, and 5
What does Fibropapilloma look like?
Fibrous core covered with stratified squamous epithelium that has hyperkeratinized outer layers.
They can be small and firm or cauliflower-like
Grayish to black in color and rough and spiny to the touch
Where on the animal are Fibropapilloma’s common?
Udder
Teats
Head, neck, shoulder
Vagina, vulva, penis, anus
What is the problem that can occur with bulls having a Fibropapilloma on the penis?
The warts grow fast and may surround the tip of the penis– rendering them unfit as studs.
Which type of BPV causes cutaneous papillomas?
Type 3
What do cutaneous papillomas look like?
Lack a fibrous core
Broad and flat
Tend to persist
What type of BPV can cause transient papillomas in the alimentary tract?
BPV-4
When _____ is ingested, the result can be transition to invasive carcinoma of the alimentary tract.
Bracken Fern
Why does Bracken Fern cause carcinoma?
Contains carcinogens, mutagens, and immunosuppressive chemicals.
When bracken fern is eaten by cattle with BPV-1 or 2, what can happen?
Enzootic hematuria that is characterized by hematuria and/or urinary bladder cancer.
How is BPV diagnosed?
TEM of biopsies
PCR
How is BPV treated?
Surgery
Cryosurgery with liquid nitrogen
Bovine IFN-Alpha
Topical agents – Podophyllin and DMSO
