Adenoviridae - Mastadenovirus - EAV-1 & EAV-2 Flashcards
1
Q
How do most EAV present?
A
Upper or lower respiratory disease
2
Q
What is EAV-1 associated as severe respiratory disease with?
A
SCID foals
As maternal AB wanes, foals die by 3 months of age :(
3
Q
What mutation causes SCID?
A
A mutation in the allele encoding for DNA-dependent protein kinase (DNA-pk) that is needed for lymphocyte VDJ recombination.
4
Q
What are the clinical signs of SCID foals with EAV-1?
A
Bronchiolitis and pneumona
Respiratory distress
5
Q
What can generalized EAV-1 infections in SCID foals case?
A
Destruction of cells in pancreas, GI tract, kidney, and bladder
