Herpesviridae - General Characteristics Flashcards
Describe the morphology.
Enveloped
Spherical to pleomorphic in shape.
150-200nm in diameter.
Icosahedral (T = 16)
How many capsomers does the capsid consist of?
162
What is the capsid surrounded by?
Tegument
Where are glycoprotein complexes embedded?
Lipid envelope
What does the viral genome look like?
Monopartite (non-segmented), linear, double-stranded, DNA
Where does viral replication and encapsidation occur?
Nucleus
How is the viral envelope acquired?
Budding through the inner layer of the nuclear envelope
How are mature virions released?
Exocytosis or cytolysis
How resistant are herpesvirus in the environment?
They aren’t.
Transmission requires close contact of mucous membranes (coitus, licking)
How is herpes virus transmitted?
Shedding of virus in nasal, oral, or genital secretions.
Direct mucous membranes.
Droplet – windy conditions promote aerosol transmission
What types of animals serve as a reservoir for transmission?
Latently infected animals
T/F Some herpesviruses are oncogenic.
True.
T/F Persistent infection with periodic or continuous shedding occurs in ALL herpesvirus infections.
True.
How is herpesvirus reactivated?
Stress caused by incurrent infections, shipping, cold, crowding, or glucocorticoid drugs
What are the inclusion bodies known as and what do they look like?
Type A Cowdry bodies
Composed of a nucleic acid and a protein
Eosinophilic intracellular inclusion bodies.
