Pancreas Flashcards
3 regions of pancreas
Head
Body
Tail
What divides the parenchyma of pancreas into lobules?
CT capsule extends septa (Trabeculae) of CT
Exocrine function of pancreas
Synthesize & secrete digestive enzymes into duodenum
Endocrine function of pancreas
Synthesize & secrete insulin & glucagon into blood (regulate glucose metabolism)
Islets of langerhans function
secrete hormones to regulate blood glucose levels
Islets of Langerhans have a rich network of ____
fenestrated capillaries
exocrine pancreas
Exocrine pancreas Secretory units are _____
Serous acini
exocrine pancreas
Serous acini are formed by…
A simple epithelium of pyramidal shaped cells
exocrine pancreas
exocrine pancreas Acinar cells are characterized by…
Distinct basophilia in basal cytoplasm and apical zymogen (secretory) granules
exocrine pancreas
Initial intercalated duct begins within the acinus with ____
Centroacinar cells
exocrine pancreas
Centroacinar cells & intercalated ducts secrete ____
Bicarbonate (HCO3- a base)
Function of bicarbonate
- Neutralize acidic chyme entering duodenum from stomach
- optimize pH for pancreatic enzyme activity
Name the 3 Pancreatic digestive enzymes in zymogen granules of acinar cells
Proteases
Lipase
Amylase
2 important proteases
Trypsinogen
Chymotrypsinogen
Pancreatic exocrine secretion is under _____ control by….
Hormonal control by hormones secreted by Enteroendocrine cells of SI
Hormones secreted by Enteroendocrine cells of SI
Secretin
Cholecystokinin (CCK)
Function of secretin
Promotes water & HCO3- secretion by pancreatic duct epithelial cells
Function of cholecystokinin (CCK)
Stimulate enzyme secretion by pancreatic acinar cells
a cells secrete ____
glucagon
function of glucagon
stimulates release of glucose into blood
B cells secrete ____
insulin
function of insulin
stimulates uptake of glucose from blood
D cells secrete ____
somatostatin
function of somatostatin
inhibits insulin & glucagon secretion
PP cells secrete ____
pancreatic polypeptide
function of pancreatic polypeptide
stimulate gastric chief cells, inhibits bile & exocrine pancreatic secretion
