Final Exam Review Flashcards

1
Q

Endocrine

Aldosterone

A
  • principal secretion of zona glomerulosa
  • major regulator of Na and K balance by increasing kidney absorption of Na and secretion of K
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2
Q

Endocrine

Herring Bodies

A
  • axonal terminal dilations in Pars Nervosa of posterior pituitary
  • where ADH and oxytocin accumulate
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3
Q

Endocrine

Infundibulum

A
  • attaches pituitary to hypothalamus
  • contains neurosecretory axons emanating from hypothalamus (hypothalamic-hypophyseal tract)
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4
Q

endocrine

parafollicular cells

A

(clear cells, C cells)
- located at periphery of follicular cells
- produce calcitonin

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5
Q

endocrine

pineal gland

A
  • main cell types: pinealocytes (melatonin) & interstitial glial cells
  • copora arenacea (brain sand) is characteristic feature
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6
Q

endocrine

Thyroid: principal cells

A
  • follicular cells = principal cells/thyrocytes
  • produce thyroid hormones (T3, T4)
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7
Q

endocrine

Parathyroid: principal cells

A
  • principal cells & oxyphil cells constitute epithelial cells of parathyroid
  • produce parathyroid hormone (PTH)
  • oxyphil cells thought to be exhausted principal cells
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8
Q

endocrine

catecholamines

A
  • chromaffin cells secrete catecholamines (epinephrine, norepinephrine)
  • regulate stress response
  • stimulate glycogen breakdown (elevate blood glucose)
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9
Q

endocrine

acidophils

A
  • one of main cells of pars distalis (pars anterior), ~40%
  • produce & secrete growth hormone & prolactin
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10
Q

renal

detrusor muscle

A

contracts to help empty bladder

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11
Q

renal

glomerular filtration barrier

A

filtration occurs through the glomerular filtration barrier
1. fenestrated capillary endothelium
2. thick combined basal laminae (GBM)
3. filtration slit pores between pedicels of podocytes (selective size barrier)

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12
Q

renal

juxtaglomerular (JG) cells

A
  • modified smooth muscle cells in tunica media of nearby afferent arteriole
  • contain secretory granules containing renin (increases BP)
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13
Q

renal

macula densa

A
  • part of juxtaglomerular apparatus (JGA) which regulates BP
  • cells monitor Na concentration of tubular fluid
  • after macula densa, DT becomes DCT
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14
Q

renal

podocytes

A
  • visceral (inner) layer of Bowman’s capsule is lined by epithelial cells called podocytes
  • podocytes from each cell body extend primary processes that curve around the capillary below
  • primary processes –> pedicels
  • spaces = filtration slit pores
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15
Q

renal

ureters

A
  • mucosa is lined by urothelium/transitional epithelium
  • at hilum, ureter expands as renal pelvis
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16
Q

renal

nephron

A
  • structural & functional unit of the kidney
  • consists of renal corpuscle & tubule system
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17
Q

renal

vasa recta

A
  • peritubular capillaries & vasa recta help modify urine in tubule system
  • involved in secretion & reabsorption
18
Q

Female reproduction

antrum

A
  • secondary follicle is characterized by a fluid containing antrum
  • fluids secreted by granulosa
  • nurtures & protects oocyte (contains growth factors, progesterone, estrogens, hyaluronic acid, etc.)
19
Q

Female reproduction

endometrium

A
  • mucosa of uterine wall
  • 2 zones: stratum functionale & stratum basale
20
Q

Female reproduction

oviduct

uterine tube/fallopian tube

A

General architecture:
- infundibulum (extensions = fimbrae)
- ampulla (fertilization occurs here)
- isthmus (narrow portion)
- uterine/intramural part (opens into uterus)

  • mucosa contains mostly simple columnar ciliated cells; peg cells
21
Q

Female reproduction

primordial follicle

A
  • each primary oocyte becomes surrounded by follicular cells forming an ovarian follicle called a primordial follicle
  • primordial follicles are earliest stage of follicle development
  • each cycle, small group of primordial follicles begin growth process
22
Q

Female reproduction

transition zone

A
  • point where endo and ectocervix meet
  • abrupt change of epithelium just outside of external os
  • most cervical cancers begin here
23
Q

Female reproduction

zona pellucida

A
  • oocyte secretes proteins forming extracellular coat called zona pellucida
  • zona pellucida proteins = glycoproteins that aid in sperm binding
24
Q

Male reproduction

epididymis

A
  • ~10-20 efferent ductules connect rete testes to epididymis
  • sperm mature and develop motility during passage through epididymis
25
Q

Male reproduction

leydig cells

A
  • each testicular lobule contains 1-4 highly coiled seminiferous tubules and CT stroma with Leydig cells
  • secrete testosterone (triggered by LH)
  • develop during puberty
26
Q

Male reproduction

seminal vesicle

A
  • mucosa: pseudostratified columnar epithelium
  • fluid produced includes fructose, prostoglandins, fibrinogen
27
Q

Male reproduction

sertoli cells

A
  • tight junctions between sertoli cells form blood-testis barrier
  • produce androgen-binding protein (concentrates testosterone)
28
Q

Male reproduction

spermiogenesis

A
  • final physical differentiation process (spermatogenic cells; no cell division)
  • spermatids condense nucleus, forms acrosome -> midpiece -> flagellum
  • spermatozoa (sperm) released from sertoli cell once mature into tubule lumen (non-motile)
29
Q

Respiratory

clara cells

A
  • mucosa of terminal bronchioles: ciliated simple cuboidal, with non-ciliated cuboidal clara cells
  • secrete surface-active agent and clara cell secretory proteins (CC16)
30
Q

Respiratory

conducting - bronchi

A
  • primary, secondary, tertiary bronchi = conducting zone
  • mucosa, muscularis, submucosa, cartilage, adventitia
  • muscularis: spiral bands of smooth m, contraction regulates diameter of bronchi
31
Q

Respiratory

Respiratory bronchioles

A
  • first part of respiratory zone
  • from terminal bronchioles to alveolar ducts
32
Q

Respiratory

Respiratory membrane

A

alveolar septum (blood-air barrier) consists of respiratory membrane:
- type 1 alveolar cells (pneumocytes)
- fused basal laminae of type 1 alveolar cells & endothelial cells of capillaries
- capillary endothelial cells

33
Q

Respiratory

larynx: vocalis muscle

A
  • skeletal muscle attached to ligament
  • tension on ligament produces different sounds
34
Q

Respiratory

surfactant

A
  • secreted by type II alveolar cells
  • surface active agent of lipoproteins & phospholipids spread over alveolar surface
  • decreases alveolar surface tension
35
Q

Respiratory

trachea

A
  • functions: conduction, conditioning
  • C-shaped rings of hyaline cartilage maintain open airway
  • open end of C rings contains trachealis muscle
  • mucosa, submucosa, cartilage, adventitia
36
Q

skin

holocrine

A
  • cells accumulate product as they mature & enlarge
  • culminate in rupture of cell and release of products
37
Q

skin

langerhans cells

A
  • dendritic APCs derived from monocytes
  • present antigens to T lymphocytes in nearby lymph nodes
  • found in stratum spinosum of epidermis
38
Q

skin

stratum lucidum

A

found only in thick skin

39
Q

skin

meissner’s

A
  • fine, light touch receptors
  • in dermal papillae (fingertips, palms, soles)
  • encapsulated nerve ending, unmyelinated ending of myelinated sensory nerve fibers following spiral path
  • schwann cells surround in helical matter -> lamellae
40
Q

skin

pilosebaceous unit

A
  • hair follicle + hair
  • arrector pili muscle
  • sebaceous gland
41
Q

skin

stratum basale

A
  • single layer of mitotically active cells, rests on basement membrane, allows epidermal renewal of new keratinocytes
  • keratinocytes undergo terminal differentiation process (keratinization) in strata, then apoptosis