P6 PATHOLOGY Flashcards
B & T lymphocytes originates from
Pluripotential stem cell
Lymphoid progenitor can develop into
- T cells
- B cells
Natural killer cells
T lymphocytes leave the BM to mature in
thymus
B lymphocytes mature in
Initially :BM
final : 2ndry lymphoid organs
surface markers of T cells
CD4
CD8
surface markers of B cells
MHC2
CD19
CD20
Antigen receptor of T cells
TCR
Antigen receptor of B cells
BCR
CD8 meaning
Cytotoxic T cells
CD4 meaning
helper T cells
products secreted by T cells
cytokines
products secreted by B cells
cytokines & antibodies
TCR polypeptides
alpha & beta or
gamma & delta
a molecule with which TCR needs to form a complex
CD3
in TCR-CD3 complex , what part mediates the signal transduction
Cytoplasmic tail of CD3
of the 2 chains of TCR polypeptides which chain needs MHC for antigen interaction
the alpha beta chain
MHC class that interacts with CD8
MHC CLASS 1 -endogenous antigens
MHC class that interacts with CD4
MHC class 2 - exogenous antigens
mention the antigen presenting cells APCs
- dendritic cells
- B cells
- macrophages
Genetic predisposition of common gamma chain defect
X LINKED
Genetic predisposition of RAG1/RAG2
ADA , JAK3 def.
autosomal recessive
immuno-phenotype in ADA
T , B , NK cells absent or low
immuno-phenotype in JAK3
NK , t cells absent or low
immuno-phenotype in IL-7R alpha
T cells absent or low
immuno-phenotype in X-SCID
NK , T cells absent or low
immuno-phenotype in RAG1/2
T , B cells low or absent
