P4 PHARMACOLOGY

Question 1

MOA of aspirin

Answer 1

inhibits TXA2 synthesis by irreversible acetylation of COX-1.

Question 2

uses of aspirin

Answer 2

for cerebrovascular & CV thrombotic events

Question 3

Duration of action of aspirin

Answer 3

last for the life span of platelets

Question 4

onset of action of aspirin

Answer 4

Rapid / 30 min

Question 5

ADR of aspirin

Answer 5

nausea, heartburn, epigastric pain
risk of intracranial hemorrhage

Question 6

MOA of Clopidogrel /
* Ticlopidine

Answer 6

ADP receptors blocker

Question 7

ADR of Clopidogrel /
* Ticlopidine

Answer 7

nausea / dyspepsia / diarrhoea

Question 8

uses of clopidogrel

Answer 8

with aspirin for immediate & long term management of PCI & stent implantation

Question 9

MOA of Abciximab
* Tirofiban & Eptifibatide

Answer 9

Reversibly block GP IIb / IIIa receptor complex to prevent cross-linkage of platelets by fibrinogen & thereby inhibit platelet aggregation.

Question 10

ADR of Abciximab
* Tirofiban & Eptifibatide

Answer 10

bleeding ,Thrombocytopenia.

Question 11

uses of Abciximab
* Tirofiban & Eptifibatide

Answer 11

• Pts undergoing PCI
• Pts receiving thrombolytic therapy for MI
• Pts with ACS

Question 12

MOA of Dipyridamole / Cilostazol

Answer 12

• inhibiting phosphodiesterase 3
• blocking the uptake of adenosine by RBCs

Question 13

ADR of Dipyridamole / Cilostazol

Answer 13

Chest pain * Facial flashing, headache
* Palpitations.

Question 14

uses of dipyridamole

Answer 14

prevent 2ndry stroke

Question 15

uses of cilostazol

Answer 15

Treatment of intermittent claudication

Question 16

3 examples of drugs that decrease platelets destruction

Answer 16

• immunoglobulin
• corticosteroids
• rituximab

Question 17

drugs that increase platelets production

Answer 17

Thrombopoietin receptor agonists

Question 18

MOA of IVIG

Answer 18

blocks Fc gamma R1 and prevent phagocytosis of platelets results in reversal of thrombocytopenia.

Question 19

ADR of IVIG

Answer 19

infusion-related reactions.
Acute renal failure and thrombosis

Question 20

MOA of Rituximab

Answer 20

Blocking of CD20 by Rituximab induces B Cells death (apoptosis).

Question 21

ADR OF Rituximab

Answer 21

Infusion-related reactions
* Lymphocytopenia leads to hepatitis B virus reactivation
* Infection

Question 22

MOA of Thrombopoietin receptor agonists

Answer 22

activating signalling that leads to increase platelet production (megakaryopoiesis)

Question 23

ADR OF Romiplostim and Eltrombopag

Answer 23

Thrombotic/thromboembolic complications