P5 PATHOLOGY

Question 1

systemic response to an infection

Answer 1

sepsis

Question 2

life threatening organ dysfunction caused by dysregulated host response to infection

Answer 2

sepsis

Question 3

sepsis clinical criteria

Answer 3

at least 3 of the these 3 :
- altered mentation
- RR of 22/min or greater
- SBP of 100 or less

Question 4

severe sepsis is characterised by

Answer 4

• oliguria
• lactic acidosis
• reduced CO
• altered mentation / coma
• resp. Distress

Question 5

profound circulatory , cellular , metabolic abnormalities associated with greater risk of mortality

Answer 5

septic shock

Question 6

septic shock is clinically identified by

Answer 6

vasopressor requirement

Question 7

Mechanisms of shock

Answer 7

• reduced effective blood volume
• reduced CO

Question 8

microbial products that imitates sepsis

Answer 8

• gram +
• gram -

Question 9

Starting signal of sepsis

Answer 9

Recognition of PAMPs

Question 10

PAMPs will activates

Answer 10

pattern recognition receptors

Question 11

give example of PRR

Answer 11

TLR / toll like receptor

Question 12

Nitric oxide systemic effects

Answer 12

fever , reduced myocardial contractility

Question 13

Nitric oxide vascular effects

Answer 13

Vasodilation , increased vascular permeability

Question 14

cytokines , NO released in septic shock causes

Answer 14

Reduced tissue perfusion

Question 15

cytokines , NO released in septic shock causes

Answer 15

Reduced tissue perfusion