P3 PATHO LAB

Question 1

acute leukaemia presentation

Answer 1

-signs of BM failure
- bleeding
- fever

Question 2

antigen marker commonly present on myeloid cells

Answer 2

CD33

Question 3

in AML , what is indicated by black arrow

Answer 3

Auer rods

Question 4

in AML ,what antigen markers are commonly detected

Answer 4

CD33 . CD13

Question 5

good prognosis marker seen in AML

Answer 5

Translocation between 8 & 21 chromosomes in cytogenetic study
& t(15;17)

Question 6

what is the diagnostic cytogenetic abnormality seen in acute premyelocytic leukaemia

Answer 6

t (15;17)

Question 7

test to be done to confirm CML diagnosis

Answer 7

cytogenetic study

Question 8

this karyotype is seen in which type of leukaemia

Answer 8

Chronic myeloid leukaemia

Question 9

cytogenetic study in CML will reveal abnormality in which chromosomes

Answer 9

the Philadelphia chromosome
Between chromosomes 9 & 22

Question 10

cella that are seen in blood smear that are Characteristic for CLL

Answer 10

smear / smudge cells

Question 11

in flow cytometry of CLL , what antigen markers are commonly detected

Answer 11

CD19 , CD5 , CD23

Question 12

levels of WBC in CLL

Answer 12

Increased

Question 13

cells present in CML blood smear

Answer 13

Mature & immature granulocytes

Question 14

minimum number of blast cells in blood/marrow required for a diagnosis of acute leukaemia ?

Answer 14

20%