P1 PHARMACOLOGY

Question 1

drug of choice for iron def. anemia

Answer 1

ferrous sulfate

Question 2

optimal levels of Hb in males

Answer 2

13 - 16.5

Question 3

optimal levels of Hb in females

Answer 3

11.6 - 15

Question 4

Content of ferrous iron in ferrous sulfate

Answer 4

65 mg

Question 5

Absorption of iron is enhanced by

Answer 5

• vitamin c
• taken on empty stomach

Question 6

Medications that reduce iron absorption

Answer 6

PPI , H2 blockers , antacids

Question 7

food that reduces iron absorption

Answer 7

tea , bran , cereals , dairy products

Question 8

Parenteral iron therapy is used for

Answer 8

-Postgastrectomy conditions
-chronic renal disease
-Intolerance to oral iron therapy

Question 9

Parenteral iron preparations

Answer 9

• dextran
• iron sucrose complex
• iron sodium gluconate complex

Question 10

route of administration of iron dextran

Answer 10

IM / IV

Question 11

route of administration of iron sucrose / iron Na complex

Answer 11

IV

Question 12

incase of anaphylactic shock due to iron dextran you will treat with

Answer 12

Epinephrine IM

Question 13

iron toxicity is treated with

Answer 13

• GI decontamination
• Deferoxamine

Question 14

Preferred route of administration for deferoxamine

Answer 14

IV

Question 15

Chronic iron overload is treated with

Answer 15

intermittent phlebotomy

Question 16

Thalassemia major patients are treated with

Answer 16

iron chelating agent

Question 17

Patients on long term treatment with metformin , PPIs , H2 blockers are at risk of developing

Answer 17

B12 deficiency

Question 18

drugs to treat B12 def.

Answer 18

-cyanocobalamin
-hydroxocobalamin

Question 19

Dosage for acute therapy for B12

Answer 19

1 mg IM daily for 7 days then once weekly for 4 weeks

Question 20

dosage for chronic therapy

Answer 20

1 mg monthly or 2 mg orally daily or 500mcg intranasally

Question 21

Preparations for folic acid def.

Answer 21

-folic acid
- folinic aci

Question 22

dosages for megaloblastic anemia due to B9 de.

Answer 22

1-5 mg po daily till complete hematological recovery

Question 23

prophylaxis of folic acid def. in Pregnant women

Answer 23

Fefol / 1 mg daily

Question 24

mention some GI side effects that you will inform your Pt about

Answer 24

nausea
constipation / diarrhoea
epigastric pain
cramps