P2 PHARMACOLOGY

Question 1

if your Pts pain score is 1-4 out of 10 , your drug of choice is

Answer 1

non opioid analgesics : NSAIDs / acetaminophen

Question 2

if your Pts pain score is 15-7 out of 10 , your drug of choice is

Answer 2

weak opioids : tramadol , codeine , hydrocodone

Question 3

if your Pts pain score is 8-10 out of 10 , your drug of choice is

Answer 3

strong opioids : morphine , hydromorphone , methadone , oxycodone , fentanyl

Question 4

max. dosage for acetaminophen per day

Answer 4

4 gm/day

Question 5

max. dosage for acetaminophen is to avoid

Answer 5

acute liver failure

Question 6

NSAIDs are contraindicated in

Answer 6

• peptic ulcer
• gastritis
• renal failure
• pregnancy

Question 7

NSAIDs are avoided in 1st trimester because they can cause

Answer 7

Miscarriage

Question 8

NSAIDs are avoided in 3rd trimester because they can cause

Answer 8

Premature closure of ductus arteriosus & prolonged gestation

Question 9

NSAIDs are avoided around 20 wks or later because they can cause

Answer 9

oligohydroamnios

Question 10

Contraindications of Pethidine

Answer 10

Pts with impaired renal function
History of seizures

Question 11

you should offer all opioid Pts

Answer 11

• laxatives
• antiemetic
• antipruritics

Question 12

Opioid antagonist of choice if RR < 10/min

Answer 12

Naloxone

Question 13

MOA of hydroxyurea

Answer 13

HbF inducer

Question 14

side effects of hydroxyurea

Answer 14

• nausea / vomiting
• neutropenia / thrombocytopenia
• leg ulcers / koilonychia
• oligospermia

Question 15

the side effects thrombocytopenia & neutropenia are due to

Answer 15

hydroxyurea myelosuppressive effect

Question 16

hydroxyurea RBC effect

Answer 16

Increased Hb

Question 17

hydroxyurea vascular effect

Answer 17

Decreased vasoconstriction