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UNIT 6 HEMATOLOGY > P1 BIOCHEM B12 METABOLISM > Flashcards

P1 BIOCHEM B12 METABOLISM Flashcards

1
Q

synthetic form of folate

A

folic acid

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2
Q

the increase in affinity of folate for folate enzymes is due to

A

the added glutamic acid residues

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3
Q

reduced & active form of folic acid

A

tetrahydrofolate TH4 / FH4

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4
Q

enzyme that forms the active form of folic acid

A

dihydrofolate reductase

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5
Q

enzyme that hydrolyses dietary folates in intestinal lumen

A

γ-glutamyl hydrolase (folate conjugase)

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6
Q

Transmembrane carries that mediates folate uptake

A

SLCA19A1 antiporter
SLC46A1 proton coupled

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7
Q

storage site for folate

A

liver & red cells

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8
Q

form of folate for storage

A

methyl TNF / polyglutamate

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9
Q

the enzyme dihydrofolate reductase requires how many molecules of NADPH

A

2

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10
Q

with what drug will folate catabolism be accelerated

A

methotrexate treatment
Anticonvulsant drugs

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11
Q

mention 3 disorders caused by folate def.

A
  • megaloblastic anemia
  • NTD
  • MTHFR def.
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12
Q

MOA of methotrexate

A
  • irreversible competitive inhibitor of dihydrofolate reductase - ultimately inhibiting DNA and RNA synthesis.
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13
Q

MOA of Sulfamethoxazole

A

inhibits the bacterial synthesis of DHF

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14
Q

MOA of Pyrimethamine (anti-malarial drug) & Trimethoprim (anti-bacterial drug)

A

inhibits DHFR and prevents the synthesis of THF

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15
Q

Transport protein of B12 from diet to ileum

A

Intrinsic factor

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16
Q

Transport protein of B12 from ileum to tissues

A

Transcobalamins 1,2,3

17
Q

B12 is important in converting what coenzyme to succinyl CoA in krebs cycle

A

Converting methylmalonyl CoA

18
Q

type of B12 anemia that is due to lack of intrinsic factors

A

Pernicious anemia

19
Q

levels of which acid will accumulate incase of V12 Def.

A

Methylmalonic acid

20
Q

elevated levels of MMA and what other acid can cause myelin damage

A

MMA & homocysteine

UNIT 6 HEMATOLOGY (33 decks)

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