P3 PHYSIOLOGY Flashcards
main function of WBC
Resistance of the body to infections
Mention the granulocytes
Neutrophils , Eosinophils & Basophils
Mention the Agranulocytes
monocytes & lymphocytes
identify this WBC
Lymphocyte
identify this WBC
Neutrophil
identify this WBC
Eosinophil
identify this WBC
Monocyte
identify this WBC
Basophil
- acid hydrolases , HOCL , defensin , peroxide enzymes…etc
all are components of
Non-specific granules
Specific granules contain
- lysozymes , lactoferrins , bacteriostatic & bactericidal products
Tertiary granules contain
- gelatinase , collagenases , hyaluronidases
WBC that increase in bacterial infection
Neutrophils
WBC that is largest in number
Neutrophils
Condition in which neutrophils are increased in number
neutrophilia
Condition in which neutrophils are low in number
neutropenia
WBC that are increased in parasitic infection & allergies
Eosinophils
color of eosinophils
red
WBC that are increased in allergies
Basophils
color of basophils
blue
WBC that are the largest in size
Monocyte
WBC that are increased in viral infections
Lymphocytes
low WBC count called
leukopenia
high WBC count called
leukocytosis
WBC that are increased in chronic infection
Monocytes
site of synthesis of lymphocytes & plasma cells
- thymus
- lymph glands
- spleen
- tonsils
- peyer’s patches
life span of WBC in blood
4-8 hrs
life span of WBC in tissues
4-6 days
monocytes in the tissues are called
macrophages
life span of lymphocytes
weeks / months
mention some chemical mediators of inflammation
Leukotrienes , interleukins , prostaglandins , histamines , TNF
ICAM stands for
Intercellular adhesion molecule
VCAM stands for
Vesicular adhesion molecule
what 3 features will help in phagocytosis
- rough surface
- dead tissue / no protection
- antibody complement complex
chemical or a protein that facilitates phagocytosis
Opsonin
give 2 examples of opsonins
C3b , antibody IgG
WBCs enter the tissue spaces by
DIAPEDESIS
WBCs are attracted to inflamed Tissue Areas by
CHEMOTAXIS
extremely bactericidal Agent
hypochlorite
Enzyme that digest thick lipid membrane that is present in some bacteria
lipase
Necrotic tissue , dead neutrophils & macrophages , tissue fluid all are found in
pus
larvacidal polypeptide released by eosinophils are called
Major basic protein
cationic proteins in eosinophils will release
hydrolytic enzymes
anti-histamine enzymes released by eosinophils are called
Histaminases
Substances released by basophils
- heparin
- bradykinin
- serotonin
- histamine
Antibody that causes allergic reaction
IgE
Basophils will look dotted in what cases
- lead poisoning
- anemia of chronic disease
- iron def. anemia
- thalassemia
name of macrophages in kidneys
mesangial cells
name of macrophages in bones
osteoclasts
name of macrophages in CNS
microglia
name of macrophages in lungs
Alveolar cells
name of macrophages in liver
kupffer cells
name of macrophages in skin
langerhans
name of macrophages in spleen & lymph nodes
histiocytes