P2 PATHOLOGY

Question 1

sites of hemolysis

Answer 1

• intravascular
• extravascular

Question 2

give disease examples of intravascular hemolysis

Answer 2

• hereditary spherocytosis
• G6PD def.
• SCD , thalassemia

Question 3

mention 2 integral RBC membrane proteins

Answer 3

BAND 3 , glycophorins

Question 4

mention 2 peripheral RBC membrane proteins

Answer 4

spectrin , ankyrin

Question 5

cause of hereditary spherocytosis

Answer 5

def. or functional abnormalities in RBcC membrane proteins

Question 6

genetic predisposition of hereditary spherocytosis

Answer 6

autosomal dominant
severe forms : autosomal recessive

Question 7

function of G6PD

Answer 7

synthesis of NADPH & GSH

Question 8

Function of GSH

Answer 8

RBC protection against oxidant damage

Question 9

you will confirm your G6PD def. Diagnosis if you see these in blood smear

Answer 9

• heinz bodies
• blister cells
• bite cells , spherocytes

Question 10

point mutation in beta globin gene will cause

Answer 10

sickle cell disease

Question 11

levels of beta globin in beta thalassemia

Answer 11

Decreased

Question 12

Levels of alpha globin in beta thalassemia

Answer 12

Increased

Question 13

in alpha thalassemia , HbH precipitates as

Answer 13

inclusion bodies

Question 14

when antibodies inhibit ADAMTS13 , Pts WILL DEVELOP

Answer 14

thrombotic thrombocytopenic purpura