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UNIT 6 HEMATOLOGY > P3 BIOCHEMISTRY > Flashcards

P3 BIOCHEMISTRY Flashcards

1
Q

Nucleotides are composed of

A
  • nitrogenous base
  • pentose monosaccharide
  • phosphate groups
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2
Q

nitrogenous bases families

A

purines , pyrimidines

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3
Q

major site of synthesis of purine

A

liver

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4
Q

sites that cannot produce purine

A

RBC , polymorphonuclear WBC , brain

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5
Q

purine synthesis pathways

A
  • de novo
  • salvage
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6
Q

in de novo pathway , nitrogen 3 & 9 are derived from

A

glutamine

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7
Q

in de novo pathway , nitrogen 1 is derived from

A

aspartate

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8
Q

how many ATPs are used in de novo pathway

A

6 ATP / 1 IMP

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9
Q

AMP , GMP precursor

A

IMP

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10
Q

enzyme that converts AMP & GMP to ATP & GTP

A

mono & diphosphate kinase

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11
Q

Committed step in de novo pathway

A

Addition of an amino group from glutamine to PRPP to form 5-phosphoribosyl-1-amine

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12
Q

source of energy in formation of AMP

A

GTP

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13
Q

source of energy in formation of GMP

A

ATP

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14
Q

regulation of AMP & GMP formation by

A

Phospho-ribosylpyrophosphate synthetase

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15
Q

Phospho-ribosylpyrophosphate
synthetase enzyme is inhibited by

A

TMP , AMP , GMP

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16
Q

ATPs used in salvage pathway

A

1 ATP

17
Q

synthesis of purine in salvage pathway is from

A

Pre-existent nucleic acids

18
Q

absence of HGPRT , Pts will develop what syndrome

A

lesch-nyhan syndrome

19
Q

lip & finger biting , gout , hyperuricemia
all are few of symptoms associated with what syndrome

A

Lesch–Nyhan syndrome

20
Q

absence of xanthine oxidase , Pts will develop

A

Xanthinuria

21
Q

a genetic disease resulting from a defect in adenosine deaminase.

A

Severe combined immunodeficiency (SCID)

22
Q

main exertion method for uric acid

A

in urine

23
Q

site of synthesis for uric acid

A

liver

24
Q

site of uric acid elimination

A

Kidneys

25
Q

Clinical conditions in which you observe high levels of uric acid

A

hyperuricemia

26
Q

Primary hyperuricemia is caused by

A

Increased production
Decreased elimination

27
Q

2ndry hyperuricemia is caused by

A
  • medications
  • cancers
  • kidney diseases
  • diabetes , acidosis
28
Q

what disease is seen in this clinical picture that is caused by progression of hyperuricemia

A

Gout

UNIT 6 HEMATOLOGY (33 decks)

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