P3 BIOCHEMISTRY Flashcards
Nucleotides are composed of
- nitrogenous base
- pentose monosaccharide
- phosphate groups
nitrogenous bases families
purines , pyrimidines
major site of synthesis of purine
liver
sites that cannot produce purine
RBC , polymorphonuclear WBC , brain
purine synthesis pathways
- de novo
- salvage
in de novo pathway , nitrogen 3 & 9 are derived from
glutamine
in de novo pathway , nitrogen 1 is derived from
aspartate
how many ATPs are used in de novo pathway
6 ATP / 1 IMP
AMP , GMP precursor
IMP
enzyme that converts AMP & GMP to ATP & GTP
mono & diphosphate kinase
Committed step in de novo pathway
Addition of an amino group from glutamine to PRPP to form 5-phosphoribosyl-1-amine
source of energy in formation of AMP
GTP
source of energy in formation of GMP
ATP
regulation of AMP & GMP formation by
Phospho-ribosylpyrophosphate synthetase
Phospho-ribosylpyrophosphate
synthetase enzyme is inhibited by
TMP , AMP , GMP
ATPs used in salvage pathway
1 ATP
synthesis of purine in salvage pathway is from
Pre-existent nucleic acids
absence of HGPRT , Pts will develop what syndrome
lesch-nyhan syndrome
lip & finger biting , gout , hyperuricemia
all are few of symptoms associated with what syndrome
Lesch–Nyhan syndrome
absence of xanthine oxidase , Pts will develop
Xanthinuria
a genetic disease resulting from a defect in adenosine deaminase.
Severe combined immunodeficiency (SCID)
main exertion method for uric acid
in urine
site of synthesis for uric acid
liver
site of uric acid elimination
Kidneys
Clinical conditions in which you observe high levels of uric acid
hyperuricemia
Primary hyperuricemia is caused by
Increased production
Decreased elimination
2ndry hyperuricemia is caused by
- medications
- cancers
- kidney diseases
- diabetes , acidosis
what disease is seen in this clinical picture that is caused by progression of hyperuricemia
Gout
