P1 PHYSIOLOGY Flashcards
an enzyme in RBCs enables it to transport HCO3
carbonic anhydrase
Elastic proteins present in RBCs membrane
ankyrin
Glycoproteins
spectrin
location of RBCs production during last month of gestation
bone marrow
location of RBCs production during middle trimester
liver
spleen , LN
location of RBCs production during early weeks of gestation
yolk sac
genesis of RBCs starts with which cell
pluripotential hematopoietic stem cell
Example of growth inducers needed for RBC genesis
IL-3
Example of differentiation inducers for RBC
low O2
Example of differentiation inducers for WBC
Infection
stage of RBC genesis where Hb appears
polychromatic erythroblast
B12 & B9 deficiency will cause
macrocytic RBC
life span of RBCs
120 days
hormone that stimulates RBCs genesis
Erythropoietin
factor that induces mRNA transcription leading to erythropoietin synthesis
Hypoxia inducible factor 1
B12 anemia due to lack of intrinsic factors
Pernicious anemia
storage form of iron
ferritin
Carrier for iron in plasma
apotransferrin
iron + apotransferrin in tissues =
Transferrin
iron carrier in cells
apoferritin
lack of transferrin leads to
hypochromic anemia
destruction of hemoglobin is by
macrophages of spleen & bone marrow
kupffer cells of liver
hormone that inhibits iron absorption & release by blocking ferroportin
hepcidin
reductase enzyme that converts fe3 to fe2
Duodenal cytochrome B
total body iron is regulated by
rate of absorption
Portion of Hb that’s converted to bilirubin
Porphyrin
