P2 BIOCHEMISTRY Flashcards
heme protein found in cardiac & red skeletal muscles
Myoglobin
Functions of myoglobin
- reservoir for O2
- O2 carrier
type of amino acids present inside myoglobin
Hydrophobic
type of amino acids present on the surface of myoglobin
hydrophilic
the proximal histidine number
His 93
the distal histidine number
His 64
His 93 function
forming bound with heme iron
His 64 function
Stabilising the bound to O2
main function of haemoglobin
Transport of O2
low oxygen affinity form of Hb is known as
deoxy form / T conformation / tense form
high oxygen affinity form of Hb is known as
oxy form / R confirmation / relaxed form
the curve shown below is known as
Oxygen dissociation curve
the normal shape of the curve for haemoglobin
sigmoidal in shape
the normal shape of the curve for myoglobin
Hyperbolic
partial pressure at which Hb is 50% saturated with O2
P50
Incase of disease , Hb O2 affinity curve shift to
the curve shifts to right or left
incase of increased P50 , the curve will shift to
right
incase of decreased P50 , the curve will shift to
left
incase of increased BPG , the curve will shift to
RIGHT
incase of decreased BPG , the curve will shift to
left
type of Hb that has a high affinity for O2
HbF
Substitution of which AA causes sickle cell disease
from glutamic acid to valine acid
Def. in beta chain production with increase in alpha chain
beta thalassemia
Def. in alpha chain production with increase in beta chain
alpha thalassemia
