P4 PATHOLOGY / MECHANISMS OF ITP Flashcards
1
Q
clinical picture of
A
immune thrombocytopenic purpura ITP
2
Q
Pts with ITP might have antibodies against
A
Platelets surface glycoproteins
3
Q
Sequestration of platelets in ITP takes place in
A
spleen , RES
4
Q
2ndry classification of ITP is due to
A
- autoimmune
- infection
- malignancy
- medications
5
Q
one of ITP therapies that impair T cell & B cell interactions
A
Splenectomy
6
Q
ITP therapy that stimulates mega-karyocyte progenitors
A
Thrombopoietin
7
Q
MOA of IV immunoglobulin ITP therapy
A
anti-idiotypic antibodies that impede antibody production.
8
Q
azathioprine and cyclosporine act on which cells
A
T cells
9
Q
Emergency ITP bleeding therapy
A
Platelet transfusions
