P3 PATHOLOGY Flashcards
what type of leukaemia is characterised with poorly diff. blast population & rapidly fatal if left untreated
Acute leukaemia
what type of leukaemia is characterised with well diff. blast population & longer survival even if left untreated
chronic leukaemia
blood smear from AML showing
Immature blast cells
blood smear from CML showing
Hyper-proliferation of myeloid cells
stain used in blood smear / BM smears in acute leukaemia
Romanowsky stain
What type of acute leukaemia is seen here with dense /clumped chromatin
ALL
What type of acute leukaemia is seen here with delicate chromatin & Auer rods
AML
what test is shown below & what does it study
immuno-phenotyping
Studying surface molecules of cells
what Monoclonal antibodies are used in AML
CD13 & CD33
what Monoclonal antibodies are used in B-ALL
CD10 , CD19 , CD22
what Monoclonal antibodies are used in T-ALL
CD3 , CD7
Unfavourable prognosis marker of ALL
- translocation in MLL gene
- t(9;22)
-hypo-ploidy
Favourable prognosis in ALL
t(12;21)
hyper-ploidy
Genetic abnormalities associated with AML
- t(8;21)
- inversion 16 / t (16;16)
- t(15;17)
what cell is shown below , that is characteristic for acute promyelocytic leukaemia
faggot cell
Unfavourable cytogenetics prognosis of AML mutation in
FLT3 mutation
Gender more at risk for CML
males
CML is characterised by which chromosomal abnormality
t(9;22) , Philadelphia chromosome
most common leukaemia in adults
chronic lymphoid leukaemia
Comment on what you observe in this blood smear of CLL case
Increase number of mature lymphocytes
what Monoclonal antibodies are used in / seen in CLL
CD 23 , CD5 , CD 19
