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UNIT 6 HEMATOLOGY > P3 PATHOLOGY > Flashcards

P3 PATHOLOGY Flashcards

1
Q

what type of leukaemia is characterised with poorly diff. blast population & rapidly fatal if left untreated

A

Acute leukaemia

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2
Q

what type of leukaemia is characterised with well diff. blast population & longer survival even if left untreated

A

chronic leukaemia

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3
Q

blood smear from AML showing

A

Immature blast cells

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4
Q

blood smear from CML showing

A

Hyper-proliferation of myeloid cells

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5
Q

stain used in blood smear / BM smears in acute leukaemia

A

Romanowsky stain

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6
Q

What type of acute leukaemia is seen here with dense /clumped chromatin

A

ALL

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7
Q

What type of acute leukaemia is seen here with delicate chromatin & Auer rods

A

AML

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8
Q

what test is shown below & what does it study

A

immuno-phenotyping
Studying surface molecules of cells

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9
Q

what Monoclonal antibodies are used in AML

A

CD13 & CD33

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10
Q

what Monoclonal antibodies are used in B-ALL

A

CD10 , CD19 , CD22

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11
Q

what Monoclonal antibodies are used in T-ALL

A

CD3 , CD7

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12
Q

Unfavourable prognosis marker of ALL

A
  • translocation in MLL gene
  • t(9;22)
    -hypo-ploidy
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13
Q

Favourable prognosis in ALL

A

t(12;21)
hyper-ploidy

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14
Q

Genetic abnormalities associated with AML

A
  • t(8;21)
  • inversion 16 / t (16;16)
  • t(15;17)
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15
Q

what cell is shown below , that is characteristic for acute promyelocytic leukaemia

A

faggot cell

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16
Q

Unfavourable cytogenetics prognosis of AML mutation in

A

FLT3 mutation

17
Q

Gender more at risk for CML

A

males

18
Q

CML is characterised by which chromosomal abnormality

A

t(9;22) , Philadelphia chromosome

19
Q

most common leukaemia in adults

A

chronic lymphoid leukaemia

20
Q

Comment on what you observe in this blood smear of CLL case

A

Increase number of mature lymphocytes

21
Q

what Monoclonal antibodies are used in / seen in CLL

A

CD 23 , CD5 , CD 19

UNIT 6 HEMATOLOGY (33 decks)

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