P6 IMMUNOLOGY HLA/MHC Flashcards
cluster of genes important in
* Immune recognition
* Signalling between cells of the immune system
HLA COMPLEX
HLA stands for
human leukocyte antigen
MHC stands for
major Histocompatibility Complex
mention the 7 groups of HLA antigens recognised
A,B,C,D,DR,,DQ,DP
class 1 MHC is found in
all nucleated cells
class 2 MHC is found in
Mononuclear cells : macrophages , lymphocytes
HLA FUNCTION
- bind & present peptides to TCR
- ligands to NK receptors
functions of CLASS 2 HLA molecules
- antigen recognition by CD8
- transplant rejection
Function of CLASS 2 HLA molecules
- antigen recognition by CD4
function of HLA typing
- paternity testing
- disease association
- donor selection for transplantation
mention at least 3 diseases associated with HLA-DR3
- celiac
- SLE
- sicca syndrome
- graves
- idiopathic addison’s
- myasthenia gravis
- insulin dependent DM
PCR methods used in HLA typing
- SSO probes
- SSP
procedures that restore stem cells that have been destroyed by high doses of chemotherapy and/or radiation therapy
bone marrow transplantation
mention the 3 types of transplantation
1- autologous
2- syngeneic
3- allogeneic
in Autologous transplants, patients receive stem cell from
Their own stem cells
in syngeneic transplants, patients receive stem cell from
Their identical twin
in allogeneic transplants, patients receive stem cell from
brother , sister , parent , unrelated donor
Mention 3 post transplant complications
GVH disease
infection
veno-occlusive liver disease
clinical manifestations of GVH disease
- jaundice
- severe diarrhoea
- skin rash
