P6 IMMUNOLOGY HLA/MHC Flashcards
cluster of genes important in
* Immune recognition
* Signalling between cells of the immune system
HLA COMPLEX
HLA stands for
human leukocyte antigen
MHC stands for
major Histocompatibility Complex
mention the 7 groups of HLA antigens recognised
A,B,C,D,DR,,DQ,DP
class 1 MHC is found in
all nucleated cells
class 2 MHC is found in
Mononuclear cells : macrophages , lymphocytes
HLA FUNCTION
- bind & present peptides to TCR
- ligands to NK receptors
functions of CLASS 2 HLA molecules
- antigen recognition by CD8
- transplant rejection
Function of CLASS 2 HLA molecules
- antigen recognition by CD4
function of HLA typing
- paternity testing
- disease association
- donor selection for transplantation
mention at least 3 diseases associated with HLA-DR3
- celiac
- SLE
- sicca syndrome
- graves
- idiopathic addison’s
- myasthenia gravis
- insulin dependent DM
PCR methods used in HLA typing
- SSO probes
- SSP
procedures that restore stem cells that have been destroyed by high doses of chemotherapy and/or radiation therapy
bone marrow transplantation
mention the 3 types of transplantation
1- autologous
2- syngeneic
3- allogeneic
in Autologous transplants, patients receive stem cell from
Their own stem cells
