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UNIT 6 HEMATOLOGY > P4 BIOCHEMISTRY > Flashcards

P4 BIOCHEMISTRY Flashcards

1
Q

a polyunsaturated omega-6 fatty acid containing 20 carbons

A

Arachidonic acid

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2
Q

Arachidonic acid is derived from desaturation & elongation of

A

linoleic acid

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3
Q

phospholipid that releases Arachidonic acid from membrane bound phospholipids

A

Phospholipase A2

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4
Q

cox pathway occurs in

A

Endoplasmic reticulum

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5
Q

Arachidonic acid is converted to prostaglandins by

A

oxidative cyclisation

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6
Q

prostaglandins generated by mast cells

A

PGD2

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7
Q

prostaglandins generated by macrophages

A

PGE2 & TXA2

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8
Q

Isozymes of coxs

A

COX -1
COX- 2

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9
Q

COX isozyme that is made in most tissues , promote or suppress leukotrienes synthesis

A

COX 1

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10
Q

COX isoenzymes that is made in brain & kidneys & macrophages

A

COX 2

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11
Q

COX 1 function

A

Maintenance of healthy gastric tissue
renal homeostasis
Platelets aggregation

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12
Q

COX 2 function

A

mediates pain , heat , redness , swelling of inflammation
Fever of infection

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13
Q

Thromboxane that is derived from prostaglandin H2

A

A type thromboxane / TXA2

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14
Q

TXA2 is present in

A

ER , lungs , platelets

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15
Q

TXA2 function

A

Stimulate platelets activation

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16
Q

half life of TXA2

A

very short , 0.5 - 1 min

17
Q

inactive form of TXA2

A

Thromboxane B2

18
Q

site of synthesis of leukotrienes

A

Leukocytes , mast cells , macrophages

19
Q

lipoxygenase enzymes that converts Arachidonic acid to variety of hydroxyperoxyl acids

A
  • 5-HPETE
    -12-HPETE
  • 15-HPETE
20
Q

5-HPETE is major product of

A

Basophils , mast cells , macrophages , polymorphs

21
Q

12-HPETE is produced in

A

platelets,
pancreatic endocrine islets cells
glomerular cells of kidney

22
Q

12-HPETE is produced by what enzyme

A

12- lipooxygenase

23
Q

15-HPETE is produced by which enzyme

A

15-lipooxygense.

24
Q

15-HPETE is produced in

A

reticulocytes, eosinophils and T cells

25
Q

The 5-HPETE is converted to LTA4 through

A

5- lipoxygenase

26
Q

LTA4 is highly unstable, and it will serve as precursors for formation

A

LTB4, LTC4, LTD4 and LTE4

27
Q

LTA4 is converted predominantly to the chemoattractant LTB4 by

A

LTA4 hydrolase

28
Q

LTA4 is conjugated with reduced glutathione by what enzyme

A

LTC4 synthase

29
Q

LTA4 is conjugated with reduced glutathione by LTC4 synthase to form

A

leukotriene C4 (LTC4)

30
Q

conversion occurs to LTC4 to produce
peptidoleukotrienes LTD4 and LTE4 by what enzyme

A

glutamyl transpeptidase & dipeptidase enzymes

UNIT 6 HEMATOLOGY (33 decks)

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