P1 BIOCHEM HEME SYNTHESIS

Question 1

incase of decreased iron levels Pt will develop

Answer 1

anemia

Question 2

incase of increased iron levels Pt will develop

Answer 2

iron overload diseases

Question 3

blood picture in iron Def. anemia

Answer 3

hypochromic microcytic

Question 4

causes of iron def. anemia

Answer 4

• nutritional
• increased demand
• inflammation
• reduced absorption

Question 5

normal serum ferritin range

Answer 5

50-200

Question 6

iron overload without tissue damage

Answer 6

hemosiderosis

Question 7

iron overload with tissue damage

Answer 7

Hemochromatosis

Question 8

hemochromatosis is due to

Answer 8

Ingested iron is not eliminated

Question 9

mention a condition that is associated with iron overload

Answer 9

Alcoholic liver disease

Question 10

more soluble form of iron

Answer 10

Ferrous / Fever 2+

Question 11

iron form less soluble at neutral / alkaline PH

Answer 11

ferric / Fe3+

Question 12

ferric form is less soluble due to

Answer 12

they form large complex anions / peroxides

Question 13

type of iron in meat , fish . Poultry

Answer 13

Heme iron

Question 14

type of of iron found in meat , fish , cereals , pulses

Answer 14

nonheme iron

Question 15

site of absorption of iron

Answer 15

Proximal duodenum & upper jejunum

Question 16

molecule that absorbs heme iron in proximal intestines

Answer 16

HT/HCP1

Question 17

reduction from ferric form to ferrous form is done by

Answer 17

Duodenal cytochrome B

Question 18

transporter protein of iron through the intestinal lumen

Answer 18

divalent metal transporter1 / DMT1

Question 19

major storage site for iron

Answer 19

liver

Question 20

major utilization site of iron

Answer 20

bone marrow

Question 21

MOA of hepcidin

Answer 21

Antagonising action of ferroportin

Question 22

site of heme synthesis

Answer 22

Erythroid cells of bone Marrow
hepatocytes

Question 23

site of synthesis of delta aminolevulinic acid

Answer 23

Mitochondria

Question 24

enzyme responsible for rate limiting step in heme synthesis

Answer 24

d-Aminolevulinate Synthase

Question 25

site of formation of porphobilinogen

Answer 25

cytoplasm

Question 26

formation of porphobilinogen is done by

Answer 26

porphobilinogen synthase /ALA Dehydrase

Question 27

element that can cause toxicity binding to ALA dehydrase

Answer 27

lead

Question 28

Process that is catalyzed by PBG deaminase

Answer 28

Formation of hydroxymethylbilane

Question 29

Protoporphyrinogen IX is converted in to protoporphyrin IX by

Answer 29

protoporphyrinogen IX oxidase.

Question 30

final reaction of heme synthesis is catalyzed by

Answer 30

ferrochelatase (heme synthase)

Question 31

RBCs are degraded by

Answer 31

Mononuclear phagocyte system/ reticuloendothelial system

Question 32

site of RBCs degradation

Answer 32

liver & spleen

Question 33

RBCs are degraded into

Answer 33

heme & globin

Question 34

heme conversion into biliverdin is done by

Answer 34

heme oxygenase

Question 35

biliverdin is converted to bilirubin is done by

Answer 35

biliverdin reductase

Question 36

disorder of heme synthesis

Answer 36

Porphyria

Question 37

Porphyria that results from lead / heavy metals / drugs

Answer 37

Acquired porphyria

Question 38

enzymes inhibited in acquired porphyria

Answer 38

- ferrochelatase - aminolevulinate dehydrase - uroporphyrinogen synthase