Ondansetron

Question 1

Ondansetron Trade Name?

Answer 1

Zofran, Zuplenz

Question 2

Ondansetron Classification?

Answer 2

Antiemetic

Question 3

Ondansetron Mechanism?

Answer 3

A Seratonin (5HT3) R and Dopamine (D2) antagonist affecting receptor sites in postrema and vagal nerve terminals which inhibits vomiting. Further, it blocks anti-peristaltic affects of apomorphine which promotes gastric and intestinal motility.

Question 4

Ondansetron Indications?

Answer 4

Nausea and/or vomiting

Question 5

Ondansetron Contraindications?

Answer 5

-Hypersensitivity
-Currently taking apomorphine

Question 6

Ondansetron Side Effects/Precautions?

Answer 6

-Headache
-Dry mouth
-Prolonged QT interval
-Heart block
-Constipation
-Diarrhea

Question 7

Ondansetron Adult Dose?

Answer 7

4mg
*CT Protocol

Question 8

Ondansetron Pediatric Dose?

Answer 8

0.15 mg/kg
*stat pearls

https://www.ncbi.nlm.nih.gov/books/NBK499839/

Question 9

Ondansetron Onset of Action?

Answer 9

Rapid Absortion. Effect in 1-30 mintues

Question 10

Ondansetron Duration of Action?

Answer 10

4-8 hours

Question 11

Ondansetron Max Dose Adult/Pediatric?

Answer 11

16mg for both
*stat pearls

Question 12

Ondansetron Routes of Administration?

Answer 12

IV/IO/IM/PO

Question 13

Ondansetron How Supplied?

Answer 13

2g/mL in 2 mL single-dose vial &
20 mL multiple-dose vial