Epinephrine

Question 1

Epinephrine Trade Name?

Answer 1

Adrenalin

Question 2

Epinephrine Classification?

Answer 2

Sympathomimetic

Question 3

Epinephrine Mechanism?

Answer 3

Non-selectively binds to a1, b1, and b2 adrenergic receptors to increase inotropy, chronotropy, dromotropy, automaticity, peripheral vasoconstriction, and bronchodilation.

Question 4

Epinephrine Indications?

Answer 4

-Cardiac arrest
-Anaphylaxis
-Severe bronchospasm
-Symptomatic bradycardia
-Non-hypovolemic shock

Question 5

Epinephrine Contraindications?

Answer 5

• None in cardiac arrest
• Hypovolemia
• Tachydysrhythmia
• Relative: heart disease, tachycardia, hypertension

Question 6

Epinephrine Side Effects/Precautions?

Answer 6

• Headache
• Syncope
• Nausea/vomiting
• Tachycardia
• Hypertension
• Dysrhythmia
• Increased myocardial oxygen demand

Question 7

Epinephrine Adult Dose?

Answer 7

• Cardiac arrest: 1 mg 1:10,000 IV/IO every 3-5 minutes
• Anaphylaxis/severe bronchospasm: 0.3-0.5 mg 1:1,000 IM
• Shock/bradycardia: 2-10 mcg/min IV/IO infusion

Question 8

Epinephrine Pediatric Dose?

Answer 8

• Cardiac arrest: 0.01 mg/kg (0.1ml/kg) 1:10,000 IV/IO every 3-5 minutes
• Anaphylaxis/severe bronchospasm: 0.01 mg/kg 1:1,000 IM
• Shock/bradycardia: 0.1-1.0 mcg/kg/min IV/IO infusion

Question 9

Epinephrine Onset of Action?

Answer 9

Immediate

Question 10

Epinephrine Duration of Action?

Answer 10

5-10 minutes IV, 20-30 minutes IM

Question 11

Epinephrine Max Dose Adult/Pediatric?

Answer 11

Adults have no maximum. Pediatric is 0.3 mg/kg for anaphylaxis and symptomatic bradycardia.

Question 12

Epinephrine Routes of Administration?

Answer 12

IV/IO/IM

Question 13

Epinephrine How Supplied?

Answer 13

• 1 mg/ml vials and ampules (1: 1,000)
• 1 mg/10ml prefilled syringes (1: 10,000)