Metoclopramide

Question 1

Metoclopramide Trade Name?

Answer 1

Reglan

Question 2

Metoclopramide Classification?

Answer 2

Antiemetic

Question 3

Metoclopramide Mechanism?

Answer 3

A Seratonin (5HT3) R and Dopamine (D2) antagonist affecting receptor sites in postrema and vagal nerve terminals which inhibits vomiting. Further, it blocks anti-peristaltic affects of apomorphine which promotes gastric and intestinal motility.

Question 4

Metoclopramide Indications?

Answer 4

-Nausea/Vomiting
-Migraine headache

Question 5

Metoclopramide Contraindications?

Answer 5

-Bowel obstruction
-Seizure Disorder
-Pheochromocytoma

Question 6

Metoclopramide Side Effects/Precautions?

Answer 6

-Extrapyramidal symptoms
-Sedation
-Drowsiness
-Fatigue
-Dizziness
-CNS depression
-Bradycardia
-Tachycardia
-Hypotension
-Hypertension
-Diarrhea

Question 7

Metoclopramide Adult Dose?

Answer 7

Nausea/Vomiting
-5-10 mg IV/IO/IM; May repeat once after 10 minutes if nausea/vomiting persists.
Pain Management - Migraine
-10 mg IV/IO infusion over 15 minutes or
-10 mg IM
*CT Protocols

Question 8

Metoclopramide Pediatric Dose?

Answer 8

Not Recommended

Question 9

Metoclopramide Onset of Action?

Answer 9

1-3 minutes IV
5-10 minutes IM
*medscape

Question 10

Metoclopramide Duration of Action?

Answer 10

1-2 hours
*medscape

Question 11

Metoclopramide Max Dose Adult/Pediatric?

Answer 11

40-60mg/day. Adults only. N/A Peds
*stat pearls

Question 12

Metoclopramide Routes of Administration?

Answer 12

IV/IO/IM

Question 13

Metoclopramide How Supplied?

Answer 13

5mg/mL vials