Oncology

Question 1

epithelium tumors

Answer 1

benign: adenoma, papilloma
malignant: adenocarcinoma, papillary carcinoma

Question 2

blood cell cancer

Answer 2

malignant leukemia or lymphoma

Question 3

blood vessel cancer

Answer 3

benign: hemangioma
malignant: angiosarcoma

Question 4

smooth muscle cancer

Answer 4

benign: leiomyoma
malignant: leiomyosarcoma

Question 5

striated muscle cancer

Answer 5

benign: rhabdomyoma
malignant: rhabdomyosarcoma

Question 6

connective tissue cancer

Answer 6

benign: fibroma
malignant: fibrosarcoma

Question 7

bone tumor

Answer 7

benign: osteoma
malignant: osteosarcoma

Question 8

fat tumor

Answer 8

benign: lipoma
malignant: liposarcoma

Question 9

carcinoma denotes

Answer 9

epithelial origin

Question 10

sarcoma denotes

Answer 10

mesenchymal origin

Question 11

CEA

Answer 11

colorectal and pancreatic cancer marker

Question 12

AFP

Answer 12

hepatocellular carcinomas, nonseminomatous germ cell tumors

Question 13

B-hCG

Answer 13

hydatidiform moles and choriocarcinoma

Question 14

CA-125

Answer 14

ovarian

Question 15

S-100

Answer 15

melanoma, neural tumors, schwannoma

Question 16

alkaline phophatase

Answer 16

mets to bone, liver, Paget’s disease

Question 17

bombesin

Answer 17

neuroblastoma, lung and gastric cancer

Question 18

TRAP

Answer 18

tartrate resistant acid phosphatase

seen in hairy cell leukemia (B cell)

Question 19

CA-19-9

Answer 19

pancreatic adenocarcinoma

Question 20

calcitonin

Answer 20

medullary thyroid carcinoma

Question 21

Psammoma bodies

Answer 21

Papillary thyroid
serous ovarian
meningioma
mesothelioma
PSaMMoma bodies

Question 22

ACTH or ACTH-like peptide

Answer 22

Cushing’s syndrome

small cell lung carcinoma

Question 23

ADH

Answer 23

SIADH

small cell lung carcinoma, intracranial neoplasms

Question 24

PTHrP

Answer 24

hypercalcemia

squamous cell lung carcinoma, renal cell, breast cancer

Question 25

1.25-OHs-D3 (calcitriol)

Answer 25

hypercalcemia | Hodgkin's

Question 26

erythropoietin

Answer 26

polycythemiarenal cell, hemangioblastoma, hepatocellular, pheochromocytoma

Question 27

Ab against Ca channels at NMJ

Answer 27

lambert-eaton | small cell lung cancer

Question 28

primary immune cell involved in host tumor immune surveilance

Answer 28

cytotoxic T cell

Question 29

how can tumor cells evade cytotoxic T cells

Answer 29

remove MHC-I from surface

Question 30

how might tumor cells induce apoptosis in T cells

Answer 30

expressing FASL on surface

Question 31

mechanism of methotrexate differ from %5-fluorouracil

Answer 31

meth: inhibits dihydrofolate reductase | 5-FU: inhibits thymidylate synthase

Question 32

body metabolize 6-mercaptopurine

Answer 32

xanthine oxidase

Question 33

rheumatoid disease and ectopic pregnancies

Answer 33

methotrexate

Question 34

alkylates DNA, toxicity is pulmonary fibrosis

Answer 34

busulfan

Question 35

fragments DNA, toxicity is pulmonary fibrosis

Answer 35

bleomycin

Question 36

blocks purine synthesis, metabolized by xanthine oxidase

Answer 36

6-mercaptopurine

Question 37

nitrogen mustard, alkylates DNA (electrophile that binds DNA)

Answer 37

nitrosureaa

Question 38

intercalates DNA, produces oxygen free radicals, cardiotoxic

Answer 38

daunorubicin, doxorubicin

Question 39

DNA alkylating agent used in brain cancer

Answer 39

nitrosureas

Question 40

applied topically for actinic keratosis and basal cell cancers

Answer 40

5-fluorouracil

Question 41

treatment for childhood tumors (Ewing, Wilms, rhabdo)

Answer 41

dactinomycin

Question 42

hemorrhagic cystitis

Answer 42

cyclophosphamide and ifosfamide

Question 43

pulmonary fibrosis

Answer 43

busulfan, bleomycin | methotrexate (fibrotic lung)

Question 44

methotrexate myelosuppression is reversible with what

Answer 44

leucovorin

Question 45

prevent cardiotoxicity of daunorubicn and doxorubicin with

Answer 45

dexrazoxane (iron chelator)

Question 46

nephrotoxic and ototoxic drugs

Answer 46

vancomycin aminoglycosides loop diuretics cisplatin and carboplatin

Question 47

used to treat choriocarcinoma

Answer 47

vincristine and methotrexate

Question 48

treat testicular cancer

Answer 48

Eradicate Ball Disease etoposide, bleomycin, cisplatin ifosfamide can replace bleomycin

Question 49

cross-link DNA, nephrotoxic, ototoxic

Answer 49

cisplatin, carboplain

Question 50

prevents tubulin disassembly

Answer 50

paclitaxel

Question 51

inhibits ribonucleotide reductase

Answer 51

hydroxyurea (S-phase specific)

Question 52

inhibitor of the mutated tyrosine kinase produced by the Philadelphia chromosome

Answer 52

imatinib

Question 53

monoclonal antibody against HER2

Answer 53

trastuzumab

Question 54

SERM that does not increase the risk of endometrial cancer

Answer 54

raloxifene

Question 55

side effects of glucocorticoids

Answer 55

BAM CUSHINGOID

Question 56

peripheral neuropathy

Answer 56

vincristine

Question 57

cardiotoxic

Answer 57

trastuzumab daunorbucin doxorubacin