Cardiovascular Flashcards
How is blood shunted from right atrium to left in the embryo?
through the foramen ovale (septum secundum) and ostium secundum (septum primum)
3 possible causes of atrial septal defect
1 ostium secundum overlaps foramen ovale
2 absence of septum secundum
3 neither septum secundum or septum primum develop
what structure grows to close the opening btw the atrial chamber and ventricular chamber into two small openings?
superior and inferior endocardial cushions
embryoligic origins: ascending aorta and pulmonary trunk coronary sinus SVC smooth parts of ventricles smooth right atrium trabeculated atria trabeculated ventricles
truncus arteriosus left horn of sinus venosus right common cardinal vein and anterior vein bulbis cordis right horn of sinus venosus primitive atria primitive ventricle
Ebstein anomaly
tricuspid leaflets are displaced into ventricle: tricuspid regurg or stenosis
patent foramen ovale common
widely split S2, tricuspid regurgitation
associated with maternal lithium use for bipolar
heart defects associated with: 22q11 deletion trisomy 21 congenital rubella turner syndrome marfan syndrome
truncus arteriosus, tetralogy endocardial cushion defects (ASD, VSD) septal defects, PDA, pulm stenosis, aortic insufficiency coarctation arotic insufficiency and dissection
boot-shaped heart
tetraolgy, RVH (adult)
rib notching
coarctation
most common congenital anomaly
VSD
most common congenital cause of early cyanosis
tetralogy
Cardiac equations
CO=HRSV
MAP=COTPR = 2/3 diastolic + 1/3 systolic
Fick’s CO= O2 consumption/(arterial O2-venous O2)
SV=EDV-ESV=CO/HR
EF=(EDV-ESV)/EDV
what congenital heart defects are helped by increasing afterload?
R -> L shunts
tetraolgy, transposition, truncus arteriosus, Eisenmenger syndrome
CHF drugs
improve survival: ACE, ARB, aldosterone antag (spironolactone), B-blockers (metoprolol, carvedilol, bisoprolol)
symptomatic relief: diuretics (loop and thiazide), digoxin, vasodilators (nitrates and hydralazine ( dec afterload))
drugs for acute heart failure
Nitrates Oxygen Loop diuretics Inotropic drugs Position
what develops from 3, 4 and 6 aortic arches
3: common carotid, proximal internal carotid
4: left: arch of adult aorta
right: proximal right subclavian
6: proximal pulmonary and ductus arteriosus
Hypovolemic shock
low output HF
increased SVR decreased CO
Rx: IV fluids, blood
Cardiogenic shock
low output HF
increased SVR decreased CO
Rx: dobutamine
Sepsis/anaphylaxis shock
high output HF
decreased SVR increased CO
Rx: antibiotics, IV fluids, norepinephrine
Neurogenic shock
decreased SVR and CO
Rx: IV fluids, steroids
Central line placements
femoral
subclavian: risk of pneumothorax
internal jugular: risk of puncturing carotid
preferred sites for Swan-Glanz catheter: right IJ > left SC > right SC > left IJ
skin in cardiogenic vs septic shock
cardiogenic: cold, clammy, cyanotic, poorly infused
septic: hot, flushed
heart sounds
S1: closing AV valves
S2: closing aortic and pulmonary valves
S3: filling enlarged space (dilated cardiomyopathy, CHF)
S4: filling against stiffened ventricle (LV hypertrophy, post MI)
benign heart sounds when no evidence of disease
Split S1
Split S2 on inspiration
S3 in pt < 40
early, quiet systolic murmur
myocardial action potential phases
Phase 0: Na open Phase 1: Na closes, K slow open Phase 2: K slow open, Ca open Phase 3: Ca closes, K fast open Phase 4: K closes
SV/AV node action potential
Phase 0: Ca open (influx)
Phase 3: K open, Ca close
Phase 4: K close, Na leak (If current)
QRS wide vs narrow
narrow: SA node is pacemaker with normal conduction
wide: abnormal conduction pathway, premature ventricular contraction (PVC), ventricular tachycardia, bundle branch block
Potassium effect on T wave
hyperkalemia: short peaked T waves
hypokalemia: wide flat T waves
vasopressor of choice for:
anaphylactic
cardiogenic
septic shock
epinephrine
dobutamine
norepi
drugs that prolong QT interval
macrolides, chloroquines (anti-infective)
haloperidol, risperidone (anti-psychotic)
methadone
anti-HIV protease inhibitors (-navir)
antiarrhythmias class IA (quinidine) and class III
drugs act on myosin light chain kinase to cause vasodilation
dihydroperidine Ca channel blockers: block calmodulin-Ca complex
epinephrin (B2) + PGE2: increase cAMP
which barorecptor senses both increases and decreases in BP
carotid baroreceptor
aortic only senses increase
paroxysms of increased sympathetic tone; anxiety, palpitations, diaphoresis
pheochromocytoma
episodic release of catecholamines
age of onset btw 20 and 50 for HTN
primary HTN
elevated serum creatinine and abnormal urinalysis with HTN
renal disease
HTN with abdominal bruit
renal artery stenosis
HTN with BP in arms>legs
coarctation of aorta
HTN with family history
primary HTN
HTN with tachycardia, heat intolerance, diarrhea
hyperthyroidism
HTN with hyperkalemia
renal failure
HTN with episodic sweating and tachycardia
pheochromocytoma
HTN with abrupt onset in pt younger than 20 or older than 50 and depressed serum K
hyperaldosteronemia
HTN with central obesity, moon-shaped face, hirsutism
Cushing syndrome
HTN with normal urinalysis and normal serum K levels
primary HTN
HTN in young pt with acute onset tachycardia
cocaine or amphetamines
HTN with hypokalemia
renal artery stenosis
HTN with proteinuria
renal disease
CXR finding in aortic dissection
widened mediastinum
treatment of aortic dissection
B-blocker
HTN with CHF
use: diuretics, ACEi/ARB, B-blocker, aldo antogonist
Avoid: B-blocker (acute decompnesated CHF or cardiogenic shock), CCB
HTN with DM
use: ACEi/ARB, thiazide (decrease strokes)
avoid: B-blocker (masks hypoglycemia)
HTN with posti-MI/CAD
use: thiazide, B-blocker, ACEi/ARB, CCB, nitrates (as needed)
HTN with atrial fibrillation
B-blocker, diltiazem/verapamil
HTN with bradycardia
avoid: B-blocker. diltiazem/verapamil
HTN with renal insufficiency
use: ACEi/ARB (for proteinuria)
avoid: ACEi/ARB (may increase creatinine), K sparing diuretics
HTN with renal artery stenosis
avoid ACEi/ARB
HTN with BPH
use a-blocker
HTN with hyperthyroidism
use propranolol
HTN with hyperparathyroidism
use: loop diuretic (loops lose Ca)
avoid: thiazide (retain Ca)
HTN with osteoporosis
use thiazide avoid loop (lose Ca)
HTN with Gout
avoid thiazides
HTN with pregnancy
Hot Moms Love Nifedipine
Hydralazine, methyldopa, labetalol, nifedipine
avoid: ACEi/ARB
HTN with migraines
use CCB, B-blocker
HTN with essential tremor
use propranolol
first dose orthostatic hypotension
a-blockers (zosin drugs)
ototoxic (especially with aminoglycosides)
loop diuretic
hypertrichosis
minoxidil
cyanide toxicity
sodium nitroprusside
dry mouth, sedation, severe rebound HTN
clonidine
bradycardia, asthma exacerbations
B-blockers
reflex tachycardia
nitrates, hydralazine, dihydropyridine CCBs
cough
ACEi
avoid in pts with sulfa allergy
loop and thiazide diuretics
possible angioedema
ACEi/ARB
development of drug-induced lupus
SHIPP
hydralazine
hypercalcemia, hypokalemia
loops and thiazides
particularly beneficial to heart failure pts
ACEi/ARB, B-blockers (carvedilol, metoprolol, bisoprolol) and aldosterone antagonists
ST segment elevation only during brief episodes of chest pain
Prinzmetal’s angina
patient is able to point to localize the chest pain using one finger
musculoskeletal
chest wall tenderness on palpation
musculoskeletal
rapid onset sharp chest pain that radiates to the scapula
aortic dissection
rapid onset sharp chest pain in a 20 year old and associated with dyspnea
spontaneous pneumothorax
occurs after heavy meals and improved by antacids
GERD
sharp pain lasting hours-days and is somewhat relieved by sitting forward
pericarditis
pain made worse by deep breathing and/or motion
musculoskeletal
chest pain in a dermatomal distribution
herpes zoster
most common cause of non-cardiac chest pain
GERD or musculoskeletal
acute onset dyspnea, tachycardia, and confusion in the hospitalized pt
Pulmonary embolism
most common locations for atherosclerosis and disorders from plaques
abdominal aorta: AAA
coronary arteries: MI, angina
popliteal artery: claudicatio/peripheral vascular disease
carotid: TIA, strokes, multi-infarct dementia
factors that increase myocardial O2 demand
preload, BP, contractility, ejection time, HR
lipid drug causes facial flushing
niacin
lipid drug causes elevated LFT and mysoitis
statins, fibrates
lipid drug causes GI discomfort, bad taste
bile acid binding resins
lipid drug causes best effect on HDL
niacin
lipid drug causes best effect on triglycerides/VLDL
fibrates, omega-3-fatty acid
lipid drug causes best effect on LDL/cholesterol
statins
lipid drug binds c. diff toxin
cholestyramine
ekg changes in MI
ST elevation, R wave decreases, Q wave hours
T wave inverts and Q wave deepens
st normal, T wave inverted, Q wave persists
ST normal, T wave normal, Q wave persists
most common lethal complication of MI
arrhythmias
chest pain, pericardial friction rub, and persistent fever occuring several weeks after an MI
Dressler syndrome
pathological characteristics of arteries in pulmonary HTN
medial hypertrophy
fibrosis of intima
arteriosclerosis
anterior wall MI leads
V1-V3, maybe 4 and 5 also
lateral wall MI
aVL, V5, V6
inferior wall MI leads
II, III, aVF
Posterior Wall MI
R precordial EKG; V4
manage a pt presenting with acute MI
ABCs MONA (IV morphine, O2, NTG, aspirin) B-bloker (metoprolol) statin (atorvastatin) antiplatelet anticoag (heparin normally) K>4, Mg>2 STEMI: cath/fibrinolysis NSTEMI: cath
long term management of MI
aspirin or clopidogrel B-blocker ACE/ARB K sparing diuretics spironolactone statins decrease weight, exercise, diet
diffuse interstitial infiltrate of lymphocytes with myocyte necrosis
myocarditis caused by coxsackie B virus
causes of dilated cardiomyopathy
ABCCCD Alcohol wet Beriberi Coxsackie B chronic Cocaine Chagas' disease Doxorubicin and daunorubicin
why does valsalva make hypertrophic cardiomyopathy louder
valsalva reduces preload, so it worsens the LV outflow obstruction by getting less blood into the heart
why does squating make a hypertrophic cardiomyopathy quieter
squatting lowers afterload, so it makes it easier to get blood past the obstruction
bacteria most associated with endocardiits
S. aureus
viridans streptococci
enterococci
staph epidermidis (artificial valves)
HACEK organisms
Haemophilus Actinobacillus Cardiobacterium Eikenella Kingella
Symptoms of endocarditis
FROM JANE Fever Roth's spots (on retina and rare) Osler's nodes (painful on fingertips) Murmur Janeway lesions (painless) Anemia Nail bed hemorrhage Emboli
IV drug users and endocarditis
S. aureus, Pseudomonas, or Candida on tricuspid valves
acute infective endocarditis
S. aureus
rapid onset (days)
affects normal valves
subacute infective endocarditis
viridans strep
insidious onset (wks to months)
effects previously damaged or congenital valves
IV drug user with chest pain, dyspnea, tachycardia, and tachypnea
Right sided endocarditis that sent embolism to pulmonary arteries
PE
motor accident with chest pain, dyspnea, tachycardia, and tachypnea
tension pneuomothorax or
fat embolism from long bone fractures
post-op pt with chest pain, dyspnea, tachycardia, and tachypnea
PE from DVT
what drug is used with infective endocarditis in ER
IV vancomycin pending culture results
splinter hemorrhages under fingernails
infective endocarditis
retinal hemorrhages with pale centers
Roth’s spots (infective endocarditis)
heart valve most commonly involved in infective endocarditis
mitral
tricuspid for IV drug users
diagnostic criteria for rheumatic fever
JONES joints (polyarthritis) Cardiac (pericarditis) nodules (subcutaneous) erythema marginatum sydenham chorea
pulsus paradoxus
decrease in systolic BP of >10mmHg with inspiration
Kussmaul’s sign
JVD during inspiration due to constrictive pericarditis (increased blood from inspiration cannot fill RV, so it backs up into SVC)
focal myocardial inflammation with multinucleate giant cells
Aschoff bodies
seen in rheumatic fever
chest pain and course rubbing heart sounds in patient with Cr of 5.0
uremic pericarditis
tree-barking of aorta
3 syphilis
child with fever, joint pain, cutaneous nodules 4 weeks after a throat infection
acute rheumatic fever
acute causes mitral regurg
chronic causes mitral stenosis
ST elevation in all EKG leads
pericarditis
EKG shows electrical alternans
cardiac tamponade
granulomatous nodules in the heart
Aschoff bodies
most common primary cardiac tumor in adults
left atria myxoma
most common primary cardiac tumor in children
rhabdomyoma
most common cause of constrictive pericarditis
US: lupus
world: TB
associated with asthma
Churg-strauss
associated with polymalgia rheumatica
giant cell (temporal) arteritis
associated with IgA nephropathy
Henoch-Schonlein purpura
Hepatitis B infection with vasculitis that spares the lungs
polyarteritis nodosa
elderly women with jaw claudication and vision loss
giant cell (temporal) arteritis
desquamation of hands/feet
Kawasaki
palpable purpura on legs
Henoch-Schonlein purpura
disorders common with Raynaud phenomenon
SLE
CREST scleroderma
Buerger disease
mixed connective tissue disease
weak pulses in upper extremities
Takayasu arteritis
necrotizing granulomas of the lung and necrotizing glomeulonephritis
granulomatosis with polyangitis (wegener’s)
necrotizing immune complex inflammation of visceral/renal vessels
polyarteritis nodosa
young asthmatics
Churg-Strauss
infants and young children; involves the coronary arteries
Kawasaki
most common vasculitis
Temporal (Giant cell)
perforation of nasal septum
Wegener’s
benign, raised, red lesion about the size of a mole in older patients
cherry hemangioma
raised, red area present at birth, increases in size initially then regresses over months to years
strawberry hemangioma
lesion caused by lymphoangiogenic growth factors in an HIV patient
Kaposi sarcoma
polypoid red lesions found in pregnancy or after trauma
pyogenic granuloma
benign, painful, red-blue tumor under fingernails
glomus tumor
cavernous lymphangioma associated with Turner syndrome
cystic hygroma
skin papule in AIDS patient caused by Bartonella
bacillary angiomatosis
cold, pale painful digits
Raynaud’s
c-ANCA
granulomatosis with polyangitis (Wgener’s)
p-ANCA
microscopic polyangitis and Churg-Strauss
treatment for Buerger disease
smoking cessation
treatment for temporal arteritis
high dose steroids