Cardiovascular Flashcards
How is blood shunted from right atrium to left in the embryo?
through the foramen ovale (septum secundum) and ostium secundum (septum primum)
3 possible causes of atrial septal defect
1 ostium secundum overlaps foramen ovale
2 absence of septum secundum
3 neither septum secundum or septum primum develop
what structure grows to close the opening btw the atrial chamber and ventricular chamber into two small openings?
superior and inferior endocardial cushions
embryoligic origins: ascending aorta and pulmonary trunk coronary sinus SVC smooth parts of ventricles smooth right atrium trabeculated atria trabeculated ventricles
truncus arteriosus left horn of sinus venosus right common cardinal vein and anterior vein bulbis cordis right horn of sinus venosus primitive atria primitive ventricle
Ebstein anomaly
tricuspid leaflets are displaced into ventricle: tricuspid regurg or stenosis
patent foramen ovale common
widely split S2, tricuspid regurgitation
associated with maternal lithium use for bipolar
heart defects associated with: 22q11 deletion trisomy 21 congenital rubella turner syndrome marfan syndrome
truncus arteriosus, tetralogy endocardial cushion defects (ASD, VSD) septal defects, PDA, pulm stenosis, aortic insufficiency coarctation arotic insufficiency and dissection
boot-shaped heart
tetraolgy, RVH (adult)
rib notching
coarctation
most common congenital anomaly
VSD
most common congenital cause of early cyanosis
tetralogy
Cardiac equations
CO=HRSV
MAP=COTPR = 2/3 diastolic + 1/3 systolic
Fick’s CO= O2 consumption/(arterial O2-venous O2)
SV=EDV-ESV=CO/HR
EF=(EDV-ESV)/EDV
what congenital heart defects are helped by increasing afterload?
R -> L shunts
tetraolgy, transposition, truncus arteriosus, Eisenmenger syndrome
CHF drugs
improve survival: ACE, ARB, aldosterone antag (spironolactone), B-blockers (metoprolol, carvedilol, bisoprolol)
symptomatic relief: diuretics (loop and thiazide), digoxin, vasodilators (nitrates and hydralazine ( dec afterload))
drugs for acute heart failure
Nitrates Oxygen Loop diuretics Inotropic drugs Position
what develops from 3, 4 and 6 aortic arches
3: common carotid, proximal internal carotid
4: left: arch of adult aorta
right: proximal right subclavian
6: proximal pulmonary and ductus arteriosus
Hypovolemic shock
low output HF
increased SVR decreased CO
Rx: IV fluids, blood
Cardiogenic shock
low output HF
increased SVR decreased CO
Rx: dobutamine
Sepsis/anaphylaxis shock
high output HF
decreased SVR increased CO
Rx: antibiotics, IV fluids, norepinephrine
Neurogenic shock
decreased SVR and CO
Rx: IV fluids, steroids
Central line placements
femoral
subclavian: risk of pneumothorax
internal jugular: risk of puncturing carotid
preferred sites for Swan-Glanz catheter: right IJ > left SC > right SC > left IJ
skin in cardiogenic vs septic shock
cardiogenic: cold, clammy, cyanotic, poorly infused
septic: hot, flushed
heart sounds
S1: closing AV valves
S2: closing aortic and pulmonary valves
S3: filling enlarged space (dilated cardiomyopathy, CHF)
S4: filling against stiffened ventricle (LV hypertrophy, post MI)
benign heart sounds when no evidence of disease
Split S1
Split S2 on inspiration
S3 in pt < 40
early, quiet systolic murmur
myocardial action potential phases
Phase 0: Na open Phase 1: Na closes, K slow open Phase 2: K slow open, Ca open Phase 3: Ca closes, K fast open Phase 4: K closes
SV/AV node action potential
Phase 0: Ca open (influx)
Phase 3: K open, Ca close
Phase 4: K close, Na leak (If current)
QRS wide vs narrow
narrow: SA node is pacemaker with normal conduction
wide: abnormal conduction pathway, premature ventricular contraction (PVC), ventricular tachycardia, bundle branch block
Potassium effect on T wave
hyperkalemia: short peaked T waves
hypokalemia: wide flat T waves
vasopressor of choice for:
anaphylactic
cardiogenic
septic shock
epinephrine
dobutamine
norepi
drugs that prolong QT interval
macrolides, chloroquines (anti-infective)
haloperidol, risperidone (anti-psychotic)
methadone
anti-HIV protease inhibitors (-navir)
antiarrhythmias class IA (quinidine) and class III
drugs act on myosin light chain kinase to cause vasodilation
dihydroperidine Ca channel blockers: block calmodulin-Ca complex
epinephrin (B2) + PGE2: increase cAMP
which barorecptor senses both increases and decreases in BP
carotid baroreceptor
aortic only senses increase
paroxysms of increased sympathetic tone; anxiety, palpitations, diaphoresis
pheochromocytoma
episodic release of catecholamines
age of onset btw 20 and 50 for HTN
primary HTN
elevated serum creatinine and abnormal urinalysis with HTN
renal disease
HTN with abdominal bruit
renal artery stenosis
HTN with BP in arms>legs
coarctation of aorta
HTN with family history
primary HTN
HTN with tachycardia, heat intolerance, diarrhea
hyperthyroidism
HTN with hyperkalemia
renal failure
HTN with episodic sweating and tachycardia
pheochromocytoma
HTN with abrupt onset in pt younger than 20 or older than 50 and depressed serum K
hyperaldosteronemia
HTN with central obesity, moon-shaped face, hirsutism
Cushing syndrome
HTN with normal urinalysis and normal serum K levels
primary HTN
HTN in young pt with acute onset tachycardia
cocaine or amphetamines
HTN with hypokalemia
renal artery stenosis
HTN with proteinuria
renal disease
CXR finding in aortic dissection
widened mediastinum
treatment of aortic dissection
B-blocker
HTN with CHF
use: diuretics, ACEi/ARB, B-blocker, aldo antogonist
Avoid: B-blocker (acute decompnesated CHF or cardiogenic shock), CCB
HTN with DM
use: ACEi/ARB, thiazide (decrease strokes)
avoid: B-blocker (masks hypoglycemia)
HTN with posti-MI/CAD
use: thiazide, B-blocker, ACEi/ARB, CCB, nitrates (as needed)
HTN with atrial fibrillation
B-blocker, diltiazem/verapamil
HTN with bradycardia
avoid: B-blocker. diltiazem/verapamil
HTN with renal insufficiency
use: ACEi/ARB (for proteinuria)
avoid: ACEi/ARB (may increase creatinine), K sparing diuretics
HTN with renal artery stenosis
avoid ACEi/ARB
HTN with BPH
use a-blocker
HTN with hyperthyroidism
use propranolol
HTN with hyperparathyroidism
use: loop diuretic (loops lose Ca)
avoid: thiazide (retain Ca)
HTN with osteoporosis
use thiazide avoid loop (lose Ca)
HTN with Gout
avoid thiazides
HTN with pregnancy
Hot Moms Love Nifedipine
Hydralazine, methyldopa, labetalol, nifedipine
avoid: ACEi/ARB
HTN with migraines
use CCB, B-blocker
HTN with essential tremor
use propranolol
first dose orthostatic hypotension
a-blockers (zosin drugs)
ototoxic (especially with aminoglycosides)
loop diuretic