immunology Flashcards
molecules expressed on antigen presenting dendritic cells
MHC 1 and II
B7
CD40
EM of a dendritic cell with Langerhans cell histiocytosis
Birbeck granule (tennis racket cells)
surface markers on B cells
CD19, 20, 21
CD 40
CDB7
IgM, IgD
What initiates V(D)J recombination
RAG-1 or RAG-2 that recognize recombination signal sequences (RSS)
what viral vaccines may be dangerous to egg allergy
influenze and yellow fever
precursor of 6-mercaptopurine
azathioprine
Ab that binds to CD3 on t cells
muromonab
Ab that binds IL-2 receptor on activated T cells
daclizumab
inhibits inosine monophophate (IMP) dehydrogenase
mycophenolate mofetil
inhibits calcineurin resulting in the loss of IL-2 and blocks T cell differentiation and activation
cyclosporine
binds FK-binding protein (FKBP) leading to loss of IL-2 production
tacrolimus
binds FKBP12 leading to inhibiton of mTOR and T cell proliferation
sirolimus
used for lupus nephritis
azathioprine
mycophenolate and cyclosporine off label
metabolized by xanthine oxidase, therefore allopurinol increases the toxicity
azathioprine
X-linked immunodeficiencies
WACH wiskott-aldrich Bruton Agammaglobulinemia \+/- chronic granulomatous disease \+/- hyper IgM syndrome
wiskott-aldrich syndrome
WAITER Wiskott aldrich immunodeficiency thrombocytopenia and purpura eczema recurrent pyogenic infections increased IgA, decreased IgM
chronic granulomatous disease cause and susceptible organisms
no NADPH oxidase
catalase + organisms:
S. aureus, E. coli, Aspargillus, Klebsiella, Candida
young pt with tetany from hypocalcemia, and candidiasis resulting from immunosuppression
thymic aplasia-> T cell deficiency
eczema, recurrent cold abscesses, high serum IgE
hyperimmunoglobulin E (Job disease)
large lysosomal vesicles in phagocytes
Chediak-Higashi defective LYST (lysosomal transport) gene
